2013 Fiscal Year Final Research Report
Involvement of metabolic enzymes and transporters in diclofenac-induced liver injury
| Project/Area Number |
23590210
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山下 哲生 (80444727)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 薬物動態・代謝学 |
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| Research Abstract |
We examined the involvement of CYP2C9, UGT2B7, MRP2 and MRP3 in induction of diclofenac (DF)-induced hepatotoxicity. In primary cultured rat hepatocytes, the knockdown for MRP2 resulted in the accumulation of DF-Glu to cells. Whereas, the knockdown for MRP3 exhibited little alterations in the accumulation of DF-Glu to cells. The higher hepatotoxicity was observed in MRP2 knockdown cells compared with MRP3 knockdown cells, suggesting that MRP2 is more important in induction of hepatotoxicity by DF.
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