2013 Fiscal Year Final Research Report
Regulation of collective cell movement by chemokine receptor CXCR7
| Project/Area Number |
23590215
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Hokkaido University |
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Principal Investigator |
FUKUI AKIMASA 北海道大学, 先端生命科学研究科(研究院), 准教授 (80262103)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 原腸形成 / 細胞集団運動 / 細胞接着 / ケモカイン / CXCR7 / 細胞内情報伝達 / CXCL12 / カドヘリン |
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| Research Abstract |
Collective cell movement is a widely observed biological event, and not a few parts of that are controlled by chemoattractants. A chemokine stromal cell-derived factor-1 (SDF-1), also known as CXCL12, functions as chemoattractant through its G-protein coupled receptor CXCR4. CXCR7, which was identified as a second receptor for SDF-1, has been focused since its novel roles have been reported as controlling cell migration to inhibit the signaling by sequestrating the SDF-1 and to signal via non-G-protein signaling pathway. In the present study, several lines of experiment suggest xCXCR7/SDF-1-dependent novel function that CXCR7 signaling modulates intercellular adhesion.
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[Journal Article] Expression of xSDF-1α, xCXCR4, and xCXCR7 during gastrulation in Xenopus laevis2013
Author(s)
Mishra, S.K., Nagata, T., Furusawa, K., Sasaki, N., Fukui, A
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Journal Title
Int. J. Dev. Biol
Volume: 57
Pages: 95-100
DOI
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