2013 Fiscal Year Final Research Report
Roles of the androgen receptor in the sexual differentiation in the mouse submandibular gland
| Project/Area Number |
23590231
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General anatomy (including Histology/Embryology)
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
WAKAYAMA Tomohiko 金沢大学, 医学系, 准教授 (70305100)
MIYUKI Yamamoto 金沢大学, 医学系, 助教 (60139780)
NAKAYA Masaaki 金沢大学, 医学系, 助教 (70422095)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 細胞分化 / 組織形成 / 顎下腺 / 顆粒性導管 / アンドロゲン / アンドロゲン受容体 / 甲状腺ホルモン |
|---|
| Research Abstract |
We examined the SMG of mice deficient of the androgen receptor (ARKO). The development of granular convoluted tubules (GCT) in ARKO male was as low as in control female. The administration of androgens had no effect, whereas the administration of thyroid hormone (T4) caused the conversion of striated duct cells into GCT cells in ARKO SMG. These results confirmed that GCT differentiation caused by androgens is dependent on the classical androgen receptor (AR), whereas that by T4 is independent of the AR. Analysis of the gene expression profiles in ARKO SMG revealed new GCT-specific genes as well as genes up-or down-regulated in the SMG by androgens without involvement of the classical AR.
|
