2013 Fiscal Year Final Research Report
Effect of troponin C affinity for Ca2+ on the frequency of arrhythmias
| Project/Area Number |
23590253
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Tohoku University |
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Principal Investigator |
MIURA Masahito 東北大学, 医学(系)研究科(研究院), 准教授 (30302110)
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| Project Period (FY) |
2011 – 2013
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| Keywords | カルシウム波 / カルシウム親和性 |
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| Research Abstract |
In cardiac ventricular muscle, the affinity of the myofilaments for Ca2+ determined the propagation velocity of Ca2+ waves. Also in the failing muscle, an increase in their affinity increased the propagation velocity. In the muscle with a regional increase in [K+]o, the increase in their affinity due to nonuniform muscle contraction increased the propagation velocity. These results suggest that the affinity of the myofilaments is an important determinant for the initiation and the frequency of ventricular arrhythmias probably by changing the velocity of Ca2+ waves.
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[Journal Article] A Sodium Channel Blocker, Pilsicainide, Produces Atrial Post-Repolarization Refractoriness through the Reduction of Sodium Channel Availability2011
Author(s)
Fukuda K, Watanabe J, Yagi T, Wakayama Y, Nakano M, Kondo M, Kumagai K, Miura M, Shirato K, Shimokawa H
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Journal Title
Tohoku J Exp Med
Volume: 225
Pages: 35-42
DOI
Peer Reviewed
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