2013 Fiscal Year Final Research Report
Role of AMP kinase in cellular proliferation and polarity in the gastrointestinal tract
| Project/Area Number |
23590272
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
INAGAKI-OHARA Kyoko 独立行政法人国立国際医療研究センター, その他部局等, その他 (70363588)
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| Co-Investigator(Renkei-kenkyūsha) |
MIHONOSHI Yasuhiko (10200099)
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| Project Period (FY) |
2011 – 2013
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| Keywords | AMPK / 胃 / レプチンシグナル |
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| Research Abstract |
AMPK, a critical molecule in leptin receptor signaling is not only an essential factor for regulation of metabolic energy balance at the whole-body level but also affects cellular proliferation.However, it remains unknown the pathophysiological role of leptin in gastrointestinal tract. We show the relevance of AMPK phosphorylation for the progression of atrophic gastritis due to a high-fat diet feeding. SInce destruction of tissue construction and metabolic energy alteration is one of oncogenic feature, it is conceivable that the effect of AMPK phosphorylation on progression of atrophic gastritis.
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Research Products
(8 results)
