2013 Fiscal Year Final Research Report
Investigation of the function of non-coding RNA in the morphogenesis
| Project/Area Number |
23590326
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KURIHARA YUKIKO 東京大学, 医学(系)研究科(研究院), 講師 (80345040)
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| Co-Investigator(Renkei-kenkyūsha) |
KURIHARA Hiroki 東京大学, 大学院医学研究科, 教授 (20221947)
UCHIJIMA Yasunobu 東京大学, 大学院医学研究科, 助手 (90272426)
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| Project Period (FY) |
2011 – 2013
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| Keywords | エンドセリン / 下顎形成 / 非コードRNA |
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| Research Abstract |
Endothelin-1/Ednra signal determines mandibular identity. Ednra homozygotes exhibited homeotic transformation of the lower jaw into an upper jaw. When we expressed the Evf2 of long noncoding in the Ednra homozygous by RMCE (recombination mediated cassette exchange), the distal part of mandible was aggravated. Evf2 controls the expressions of principal genes under Endothelin-1/Ednra signaling directly and indirectly. DNA methylation and long non-coding RNA were possibly suggested as the underlying mechanism.
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Research Products
(11 results)
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[Journal Article] Endothelin regulates neural crest deployment and fate to form great vessels through Dlx5/Dlx6-independent mechanisms2013
Author(s)
Kim KS, Arima Y, Kitazawa T, Nishiyama K, Asai R, Uchijima Y, Sato T, Levi G, Kitanaka S, Igarashi T, Kurihara Y, Kurihara H
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Journal Title
Mech Dev
Volume: 130(11-12)
Pages: 553-566
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[Journal Article] Preotic neural crest cells contribute to coronary artery smooth muscle involving endothelin signalling2012
Author(s)
Arima Y, Miyagawa-Tomita S, Maeda K, Asai R, Seya D, Minoux M, Rijli FM, Nishiyama K, Kim KS, Uchijima Y, Ogawa H, Kurihara Y, Kurihara H
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Journal Title
Nat Commun
Volume: 3
Pages: 1267
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[Journal Article] Calcitonin gene-related peptide facilitates revascularization during hindlimb ischemia in mice2011
Author(s)
Mishima T, Ito Y, Hosono K, Tamura Y, Uchida Y, Hirata M, Suzsuki T, Amano H, Kato S, Kurihara Y, Kurihara H, Hayashi I, Watanabe M, Majima M
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Journal Title
Am J Physiol Heart Circ Physiol
Volume: 300(2)
Pages: H431-439
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