2014 Fiscal Year Final Research Report
Actin filament assembly during myofibrillogenesis
| Project/Area Number |
23590337
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | University of Miyazaki (2013)
Kyushu University (2011-2012) |
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Principal Investigator |
TAKEYA Ryu 宮崎大学, 医学部, 教授 (50335981)
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| Project Period (FY) |
2011 – 2014
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| Keywords | サルコメア / アクチン / 心筋 / 筋原線維 / 発生・分化 / 細胞・組織 / 循環器 |
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| Outline of Final Research Achievements |
Fhod3 is a cardiac member of the formin family proteins that play pivotal roles in actin filament assembly. In the present study, we show that Fhod3 KO mice appear normal up to embryonic day (E) 8.5, but fail to develop further and died by E11.5 with aborted development of myofibrils. These findings indicate that actin dynamics, regulated by Fhod3, participate in sarcomere organization during myofibrillogenesis and thus play a crucial role in heart development.
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| Free Research Field |
分子細胞薬理学
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