2013 Fiscal Year Final Research Report
Investigation for complement D factor activation by MASP-1/3
| Project/Area Number |
23590342
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 補体 / MASP / ノックアウトマウス / 3MC症候群 / レクチン経路 |
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| Research Abstract |
In complement system, lectin pathway activates complement by recognition of sugar chains on microbes. MASP has a pivotal role in the lectin pathway. Three MASPs (MASP-1, MASP-2 and MASP-3) were identified. We reported that MASP-1/3 activate complement D factor(fD), which is essential for the alternative pathway. In this study, we will investigate the mechanisms for activation of fD by MASP-1/3. During this study, MASP-1/3 defected patients were found. We found that MASP1/3 is essential for alternative pathway in human as well as mouse.
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[Journal Article] Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement2011
Author(s)
Banda N. K., Takahashi M., Takahashi K., Stahl G. L., Hyatt S., Glogowska M., Wiles T. A., Endo Y., Fujita T., Michael Holers V., Arend W. P.
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Journal Title
Mol Immunol
Volume: 49
Pages: 281-289
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[Journal Article] Mannose-binding lectin, its associated proteases (MASPs) mediate coagulation, its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation2011
Author(s)
Takahashi K., Chang W. C., Takahashi M., Pavlov V., Ishida Y., La Bonte L., Shi L., Fujita T., Stahl G. L., Van Cott E. M.
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Journal Title
Immunobiology
Volume: 216
Pages: 96-102
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[Journal Article] Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial, gastrointestinal ischemia/reperfusion injury2011
Author(s)
Schwaeble W. J., Lynch N. J., Clark J. E., Marber M., Samani N. J., Ali Y. M., Dudler T., Parent B., Lhotta K., Wallis R., Farrar C. A., Sacks S., Lee H., Zhang M., Iwaki D., Takahashi M., Fujita T., Tedford C. E., Stover C. M.
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Journal Title
Proc Natl Acad Sci U S A
Volume: 108
Pages: 7523-7528
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