2013 Fiscal Year Final Research Report
Role of EP4 receptor-associated protein in regulating macrophage activation
| Project/Area Number |
23590361
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
MINAMI Manabu 京都大学, 医学(系)研究科(研究院), 助教 (90511907)
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| Co-Investigator(Renkei-kenkyūsha) |
SENO Hiroshi 京都大学, 大学院医学研究科, 講師 (90335266)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 分子病態学 / マクロファージ / 慢性炎症 / 細胞内シグナル伝達 |
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| Research Abstract |
In this study we aimed to dissect the significance and pathophysiological roles of EP4 receptor-associated protein, EPRAP, a novel cytoplasmic regulator of macrophage activation. We generated EPRAP-deficient mice as well as transgenic mice with enforced expression of EPRAP specifically in macrophages. We used these mice and created animal models of human inflammatory bowel diseases and pulmonary fibrosis. In both experiments, EPRAP deficiency markedly increased infiltrated macrophage activation and local inflammation, resulting in significant decrease in survival rates. In addition, we figured out that EPRPA mitigated the MEK-ERK pathway activation and inhibited macrophage activation in the inflamed lesions. Our results indicated that EPRAP plays crucial roles in the pathogenesis and outcome of various inflammatory diseases by regulating macrophage activation in vivo.
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Research Products
(25 results)
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[Journal Article] Dclk1 distinguishes between tumor and normal stem cells in the intestine2013
Author(s)
Nakanishi Y, Seno H, Fukuoka A, Ueo T, Yamaga Y, Maruno T, Nakanishi N, Kanda K, Komekado H, Kawada M, Isomura A, Kawada K, Sakai Y, Yanagita M, Kageyama R, Kawaguchi Y, Taketo MM, Yonehara S, Chiba T
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Journal Title
Nat Genet
Volume: 45 (1)
Pages: 98-103
DOI
Peer Reviewed
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[Journal Article] Inhibitory role of Gas6 in intestinal tumorigenesis2013
Author(s)
Akitake-Kawano R, Seno H, Nakatsuji M, Kimura Y, Nakanishi Y, Yoshioka T, Kanda K, Kawada M, Kawada K, Sakai Y, Chiba T
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Journal Title
Carcinogenesis
Volume: 34 (7)
Pages: 1567-1574
DOI
Peer Reviewed
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[Journal Article] An international survey of physicians regarding clinical trials: a comparison between Kyoto University Hospital and Seoul National University Hospital2013
Author(s)
Ito-Ihara T, Hong JH, Kim OJ, Sumi E, Kim SY, Tanaka S, Narita K, Hatta T, Choi EK, Choi KJ, Miyagawa T, Minami M, Murayama T, Yokode M
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Journal Title
BMC Med Res Methodol
Volume: 13
Pages: 130
DOI
Peer Reviewed
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[Journal Article] SR-PSOX/CXCL16 plays a critical role in the progression of colonic inflammation2011
Author(s)
Uza, N, H. Nakase, S. Yamamoto, T. Yoshino, Y. Takeda, S. Ueno, S. Inoue, S. Mikami, M. Matsuura, T. Shimaoka, N. Kume, M. Minami, S. Yonehara, H. Ikeuchi, T. Chiba
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Journal Title
Gut
Volume: 60(11)
Pages: 1494-1505
DOI
Peer Reviewed
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[Journal Article] COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps2011
Author(s)
Nakanishi, Y., M. Nakatsuji, H. Seno, S. Ishizu, R. Akitake-Kawano, K. Kanda, T. Ueo, H. Komekado, M. Kawada, M. Minami, T. Chiba
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Journal Title
Carcinogenesis
Volume: 32(9)
Pages: 1333-1339
DOI
Peer Reviewed
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