2013 Fiscal Year Final Research Report
Reproduction of pancreatic islet in the pancreas by gene therapy
| Project/Area Number |
23590378
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
KOJIMA HIDETO 滋賀医科大学, 医学部, 准教授 (00225434)
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Hiroshi 滋賀医科大学, 医学部, 名誉教授 (00110560)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 遺伝子治療 |
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| Research Abstract |
For the treatment of a mouse model of insulin-dependent diabetes mellitus, we used nanodiamonds to deliver DNA for gene-therapy aiming the differentiation of the pancreatic islet from progenitor cells localized in the pancreatic duct epithelium. By an application of plasmid DNA coding a fluorescent dye we clearly observed the dye expression at the position of pancreatic duct, indicating that the vector system performed its role for gene delivery to the pancreatic ducts. Next, we need to examine the usefulness of the vector in the pancreatic islet regeneration.
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Research Products
(9 results)
