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2013 Fiscal Year Final Research Report

Identification and characterization of target genes for the language-related human and chimpanzee FOXP2

Research Project

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Project/Area Number 23590383
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human genetics
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

OIKAWA TSUNEYUKI  北海道医療大学, 心理科学部, 教授 (80150241)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Kenshi  北海道医療大学, 心理学, 助教 (60583903)
OHTA Tohru  北海道医療大学, 個体差健康科学研究所, 准教授 (10223835)
Project Period (FY) 2011 – 2013
Keywords言語関連遺伝子 / 転写因子
Research Abstract

Mutations of the FOXP2 gene have been reported in families of specific language impairment in human. Two amino acid changes occurred in the FOXP2 genes during evolution from primate lineages to human being. Thus, the FOXP2 have been focused as an attractive gene to elucidate molecular mechanisms of language development.
We have previously performed a screening to isolate the associated genes with FOXP2 over exogenous expression in hek293 cell, using micro array techniques.
We performed again statistical comparisons for the data using 2way ANOVA. In this screening, positive genes were only 2 genes affected by Tg Human FOXP2, 31 genes by Tg Human FOXP2 isoform, and 6 genes by Tg chimpanzee FOXP2. The neuroblastoma cell lines with each randomly stable integrated Tg FOXP2 were generated. The common feature of the gene expression affected exogenous Tg in both hek293 and neuroblastoma cell were observed in several genes. These genes were associated with extracellular matrix and glia cell.

  • Research Products

    (19 results)

All 2013 2012 2011

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (10 results) (of which Invited: 1 results)

  • [Journal Article] MLL2 and KDM6A mutations in patients with Kabuki syndrome2013

    • Author(s)
      Miyake N, Koshimizu E, Okamoto N, Mizuno S, Ogata T, Nagai T, Kosho T, Ohashi H, Kato M, Sasaki G, Mabe H, Watanabe Y, Yoshino M, Matsuishi T, Takanashi J, Shotelersuk V, Tekin M, Ochi N, Kubota M, Ito N, Ihara K, Hara T, Tonoki H, Ohta T, Saito K, Matsuo M, Urano M, Enokizono T, Sato A, Tanaka H, Ogawa A, Fujita T, Hiraki Y, Kitanaka S, Matsubara Y, Makita T, Taguri M, Nakashima M, Tsurusaki Y, Saitsu H, Yoshiura K, Matsumoto N, Niikawa N
    • Journal Title

      Am J Med Genet A

      Volume: 161(9) Pages: 2234-2243

    • Peer Reviewed
  • [Journal Article] Clinical correlations of mutations affecting six components of the SWI/SNF complex : detailed description of 21 patients and a review of the literature2013

    • Author(s)
      Kosho T, Okamoto N, Ohashi H, Tsurusaki Y, Imai Y, Hibi-Ko Y, Kawame H, Homma T, Tanabe S, Kato M, Hiraki Y, Yamagata T, Yano S, Sakazume S, Ishii T, Nagai T, Ohta T, Niikawa N, Mizuno S, Kaname T, Naritomi K, Narumi Y, Wakui K, Fukushima Y, Miyatake S, Mizuguchi T, Saitsu H, Miyake N, Matsumoto N
    • Journal Title

      Am J Med Genet A

      Volume: 161(6) Pages: 1221-1237

    • Peer Reviewed
  • [Journal Article] Clinical phenotype and candidate genes for the 5q31.3 microdeletion syndrome2012

    • Author(s)
      Hosoki K, Ohta T, Natsume J, Imai S, Okumura A, Matsui T, Harada N, Bacino CA, Scaglia F, Jones JY, Niikawa N, Saitoh S
    • Journal Title

      Am J Med Genet A

      Volume: 158A(8) Pages: 1891-1896

    • Peer Reviewed
  • [Journal Article] Hand-foot-genital syndrome with a 7p15 deletion : clinically recognizable syndrome2012

    • Author(s)
      Hosoki K, Ohta T, Fujita K, Nishigaki S, Shiomi M, Niikawa N, Saitoh S
    • Journal Title

      Pediatr Int

      Volume: 54(3) Pages: e22-e25

    • Peer Reviewed
  • [Journal Article] Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome2012

    • Author(s)
      Tsurusaki Y, Okamoto N, Ohashi H, Kosho T, Imai Y, Hibi-Ko Y, Kaname T, Naritomi K, Kawame H, Wakui K, Fukushima Y, Homma T, Kato M, Hiraki Y, Yamagata T, Yano S, Mizuno S, Sakazume S, Ishii T, Nagai T, Shiina M, Ogata K, Ohta T, Niikawa N, Miyatake S, Okada I, Mizuguchi T, Doi H, Saitsu H, Miyake N, Matsumoto N
    • Journal Title

      Nat Genet

      Volume: 44(4) Pages: 376-378

    • Peer Reviewed
  • [Journal Article] 遺伝学的基礎Prader-Willi症候群の基礎と臨床2011

    • Author(s)
      太田亨
    • Journal Title

      診断と治療社

      Pages: 7-14

  • [Journal Article] A polymerase chain reaction-based method for constructing a linear vector with site-specific DNA methylation2011

    • Author(s)
      Arakawa T, Ohta T, Abiko Y, Okayama M, Mizoguchi I, Takuma T
    • Journal Title

      Anal Biochem

      Volume: 416(2) Pages: 211-217

    • Peer Reviewed
  • [Journal Article] Spectrum of MLL2 (ALR) mutations in 110 cases of Kabuki syndrome2011

    • Author(s)
      Hannibal MC, Buckingham KJ, Ng SB, Ming JE, Beck AE, McMillin MJ, Gildersleeve HI, Bigham AW, Tabor HK, Mefford HC, Cook J, Yoshiura K, Matsumoto T, Matsumoto N, Miyake N, Tonoki H, Naritomi K, Kaname T, Nagai T, Ohashi H, Kurosawa K, Hou JW, Ohta T, Liang D, Sudo A, Morris CA, Banka S, Black GC, Clayton-Smith J, Nickerson DA, Zackai EH, Shaikh TH, Donnai D, Niikawa N, Shendure J, Bamshad MJ
    • Journal Title

      Am J Med Genet A

      Volume: 155A(7) Pages: 1511-1516

    • Peer Reviewed
  • [Journal Article] Down-regulation of ABCC11 protein (MRP8) in human breast cancer2011

    • Author(s)
      Sosonkina N, Nakashima M, Ohta T, Niikawa N, Starenki D
    • Journal Title

      Exp Oncol

      Volume: 33(1) Pages: 42-46

    • Peer Reviewed
  • [Presentation] Identification of target genes for the language-related FOXP2 and its isoform2012

    • Author(s)
      Ohta T. Niikawa N. Oikawa T
    • Organizer
      The 62nd Annual Meeting of the American Society of Human Geetics
    • Place of Presentation
      BOSTON, USA
    • Year and Date
      20120000
  • [Presentation] 微細染色体異常の同定されたAngelman症候群様表現型を呈する症例2012

    • Author(s)
      細木華奈, 太田亨, 新川詔夫, 小崎健次郎, 齋藤伸治
    • Organizer
      第57回日本人類遺伝学会
    • Place of Presentation
      東京
    • Year and Date
      20120000
  • [Presentation] 言語関連転写因子FOXP2のisoformの機能と標的遺伝子の同定2012

    • Author(s)
      太田亨, 及川恒之, 新川詔夫
    • Organizer
      第57回日本人類遺伝学会
    • Place of Presentation
      東京
    • Year and Date
      20120000
  • [Presentation] 過去8年間(2004~2012年)に天使病院小児科遺伝外来を受診しマイクロアレイを用いたゲノム解析を行った患者の検討2012

    • Author(s)
      徳富智明, 太田亨, 齋藤伸治, 奥原宏治, 飯塚進, 高橋伸浩, 小畑慶子, 新川詔夫, 外木秀文
    • Organizer
      第57回日本人類遺伝学会
    • Place of Presentation
      東京
    • Year and Date
      20120000
  • [Presentation] ホルモン非抵抗性先端異骨症のエクソーム解析2012

    • Author(s)
      要匡, 柳久美子, 小口良子, 成富研二, 當間隆也, 近藤達郎, 二井英二, 外木秀文, 西村玄, 吉浦孝一郎, 太田亨, 新川詔夫, 松浦信夫, Dong-Kyu Jin
    • Organizer
      第57回日本人類遺伝学会
    • Place of Presentation
      東京
    • Year and Date
      20120000
  • [Presentation] Angelman症候群とPrader-Willi症候群のエピジェネティックス2012

    • Author(s)
      太田亨
    • Organizer
      第54回歯科基礎医学会学術大会・総会・サテライトシンポジウム
    • Place of Presentation
      郡山市
    • Year and Date
      20120000
    • Invited
  • [Presentation] 言語関連転写因子FOXP2の標的遺伝子の同定2011

    • Author(s)
      太田亨, 松田律史, 及川恒之, 新川詔夫
    • Organizer
      第56回日本人類遺伝学会・第11回東アジア人類遺伝学会
    • Place of Presentation
      千葉
    • Year and Date
      20110000
  • [Presentation] 5q31.3欠失症候群は新規の染色体微細欠失症候群である2011

    • Author(s)
      細木華奈, 太田亨, 夏目淳, 今井純好, 奥村彰久, 松井健, 原田直樹, Scaglia Fernando, Bacino Carlos, 新川詔夫, 齋藤伸治
    • Organizer
      第56回日本人類遺伝学会・第11回東アジア人類遺伝学会
    • Place of Presentation
      千葉
    • Year and Date
      20110000
  • [Presentation] ポアソン回帰及びモデル選択の多因子マイクロアレイ実験への適応2011

    • Author(s)
      松田律史,加茂憲一,太田亨,及川恒之,新川詔夫
    • Organizer
      第34回日本分子生物学会年回
    • Place of Presentation
      横浜
    • Year and Date
      20110000
  • [Presentation] 5q31.3 microdeletion syndrome is a clinically discernible new syndrome characterized by severe neonatal hypotonia, feeding difficulties, respiratory distress, and severe developmental delay2011

    • Author(s)
      Hosoki K, Ohta T, Natsume J, Imai S, Okumura A, Matsui T, Harada N, Scaglia F, Bacino CA, Niikawa N, Saitoh S
    • Organizer
      The 12th International Congress of Human Genetics / The 61st Annual Meeting of the American Society of Human Geetics
    • Place of Presentation
      Montreal, CANADA
    • Year and Date
      20110000

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Published: 2015-07-16  

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