Pathological research on angiogenic growth factors that have the aspects of vascular repair and injury

2013 Fiscal Year Final Research Report

• Project/Area Number: 23590400
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Kyushu University
• Principal Investigator: NAKANO TOSHIAKI 九州大学, 大学病院, 助教 (10432931)
• Co-Investigator(Kenkyū-buntansha): ONIMARU Mitsuho 九州大学, 医学研究院, 助教 (00380626) ; TSURUYA Kazuhiko 九州大学, 医学研究院, 准教授 (20372740) ; TANIGUCHI Masatomo 九州大学, 医学研究院, 助教 (60419562)
• Project Period (FY): 2011 – 2013
• Keywords: 血管新生 / 動脈硬化 / 慢性腎臓病

Research Abstract

Atherosclerotic diseases are increasing as lifestyle-related diseases increased. We investigated the mechanisms of vascular impairments with the focus on angiogenic growth factors in several diseases. We revealed that VEGF-A and VEGF-C progressed atherosclerotic lesions of ApoE-KO mice. CKD is associated with an increased risk of coronary heart disease caused by the acceleration of chronic inflammation. In peritoneal dialysis patients, immature angiogenesis in peritoneum is related with peritoneal dysfunction. Lymphangiogenesis in renal cortex may improve interstitial damages in ureteral obstruction mice. From these findings, angiogenic growth factors have the effects of vascular repairs and injuries in various types of diseases.

Research Products

• [Journal Article] Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders : results from the Hisayama Study (2013)
  • Author(s): Nakano T, Ninomiya T, Sumiyoshi S, Onimaru M, Fujii H, Itabe H, Nakashima Y, Sueishi K, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y
  • Journal Title: Kidney Int. Volume: 84(2) Pages: 373-80
• [Presentation] Glucose degradation product methylglyoxal induces immature angiogenesis and peritoneal dysfunction in peritoneal membrane in patients undergoing peritoneal dialysis American Society of Nephrology (2013)
  • Author(s): Nakano T, Mizumasa T, Yoshida H, Eriguchi M, Taniguchi M, Masutani K, Hirakata H, Tsuruya K, Kitazono T
  • Organizer: Kidney Week 2013 Annual Meeting
  • Place of Presentation: Atlanta, GA
  • Year and Date: 2013-11-08
• [Presentation] Calcification is a risk factor for intraplaque hemorrhage in coronary atherosclerosis of patients with chronic kidney disease : the Hisayama Study American Society of Nephrology (2013)
  • Author(s): Nakano T, Ninomiya T, Onimaru M, Tsuruya K, Kiyohara Y, Kitazono T
  • Organizer: Kidney Week 2013 Annual Meeting
  • Place of Presentation: Atlanta, GA
  • Year and Date: 2013-11-07
• [Presentation] カルボニルストレスは腹膜の非機能的血管新生と透過性亢進に影響する (2013)
  • Author(s): 中野敏昭, 水政透, 吉田寿子, 田中茂, 江里口雅裕, 升谷耕介, 鶴屋和彦, 平方秀樹, 北園孝成
  • Organizer: 第19回日本腹膜透析医学会学術集会・総会
  • Place of Presentation: 大阪
  • Year and Date: 2013-09-28
• [Presentation] 腹膜透析中止期における腹膜毛細血管数の腹膜機能への影響 (2012)
  • Author(s): 中野敏昭, 水政透, 吉田寿子, 谷口正智, 鶴屋和彦, 平方秀樹, 北園孝成
  • Organizer: 第18回日本腹膜透析医学会学術集会・総会
  • Place of Presentation: 徳島
  • Year and Date: 2012-09-22
• [Presentation] The Effect of Kidney Function on Intimal Neovascularization and Intraplaque Hemorrhage in Coronary Atherosclerosis : the Hisayama Study American Society of Nephrology (2011)
  • Author(s): Nakano T, Ninomiya T, Onimaru M, Tsuruya K, Kiyohara Y, Kitazono T
  • Organizer: Kidney Week 2011 Annual Meeting
  • Place of Presentation: Philadelphia, PA
  • Year and Date: 2011-11-12
• [Presentation] 腎機能障害による冠状動脈内血管新生と内膜内出血への影響 (2011)
  • Author(s): 中野敏昭, 二宮利治, 鬼丸瑞穂, 鶴屋和彦, 清原裕, 北園孝成
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-17