Relationship between Histamine releasing Factor and rheumatoid arthritis

2013 Fiscal Year Final Research Report

• Project/Area Number: 23590417
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Tokyo Medical University
• Principal Investigator: ISHIKAWA Akio 東京医科大学, 医学部, 助手 (80468652)
• Co-Investigator(Kenkyū-buntansha): TAKANASHI Masakatsu 東京医科大学, 医学部, 講師 (80312007) ; SUDO Katsuko 東京医科大学, 医学部, 兼任講師 (50126091) ; UEDA Shinobu 東京医科大学, 医学部, 助手 (00521874)
• Project Period (FY): 2011 – 2013
• Keywords: HRF / リウマチ関節炎 / ヒスタミン

Research Abstract

We made an antibody against HRF to elucidate mechanism for allergic diseases such as a rheumatic arthritis (RA) and controlled the development after the injection of antibody to RA model mice. It is still unclear the correlation with between HRF and RA. To study the association between HRF and allergy, we tried to make RA mouse and atopic dermatitis (AD) mouse. In RA and AD model mice, cellular infiltrations were found as lymphocytes and macrophages and mast cells in the inflammatory region. In these animals IgE and histamine productions decreased. We analyzed the property of the HRF antibody to examine the expression of HRF with the model mice. These results showed the possibility that it could become the materials which examined the correlation between the allergic disease with HRF.

Research Products

• [Journal Article] miRNA-18a modulates STAT3 activity through negative regulation of PIAS3 during gastric adenocarcinogenesis (2013)
  • Author(s): Wu W., Takanashi M., Borjiigin N., Ohno S., Fujita K., Hoshino S., Osaka Y., Tsuchida A., Kuroda M
  • Journal Title: British J. Cancer Volume: 108(3) Pages: 653-661
  • DOI: 10.1038/bjc.2012.587
  • Peer Reviewed
• [Journal Article] Isolation of mRNAs that target EGFR mRNA in human lung cancer (2012)
  • Author(s): Yamaguchi G, Takanashi M., Fujita K., Ohira T., Kuroda M., Ikeda N
  • Journal Title: Biochem Biophys Res Commun. Volume: 420(2) Pages: 411-416
  • DOI: 10.1016/j.bbrc.2012.03.008
  • Peer Reviewed
• [Journal Article] Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells (2012)
  • Author(s): Ohno S., Takanashi M., Sudo K., Ueda S., Ishida A., Matsuyama N., Fujita K., Mizitani T., Ohgi T., Ochiya T., et. Al
  • Journal Title: Mol. Ther. Volume: 21(1) Pages: 185-191
  • DOI: 10.1038/mt.2012.180
  • Peer Reviewed
• [Journal Article] TLS-CHOP represses miR-486 expression, inducing upregulation of a metastasis regulator PAI-1 in human myxoid liposarcoma (2012)
  • Author(s): Borjigin N., Ohno S., Wu W., Tanaka M., Suzuki R., Fujita K., Takanashi M., Oikawa K., et. Al
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 27(2) Pages: 355-360
  • DOI: 10.1016/j.bbrc.2012.09.063
  • Peer Reviewed
• [Journal Article] A novel oncogenic pathway by TLS- CHOP involving repression of MDA-7/ IL-24 expression (2012)
  • Author(s): Oikawa K., Tanaka S., Itoh S., Takanashi M., Ozaki T., Muragaki Y., Kuroda M.
  • Journal Title: British J. Cancer Volume: 106(12) Pages: 1976-1979
  • DOI: 10.1038/bjc.2012.199
  • Peer Reviewed
• [Journal Article] Identification of a novel role of Septin 10 in paclitaxel-resistance in cancers through a functional genomics screen (2012)
  • Author(s): Xu M., Takanashi M., Oikawa K., Nishi H., Isaka K., Yoshimoto T., Ohyashiki J., Kuroda M.
  • Journal Title: Cancer Sci. Volume: 103(4) Pages: 821-827
  • DOI: 10.1111/j.1349-7006.2012.02221.x
  • Peer Reviewed
• [Journal Article] miR-92 is a key oncogenic component of the miR-17-92 cluster in colon cancer (2011)
  • Author(s): Tsuchida A., Ohno S., Wu W., Borjigin N., Fujita K., Aoki T., Ueda S., Takanashi M., Kuroda M.
  • Journal Title: Cancer Sci. Volume: 102(12) Pages: 2264-2271
  • Peer Reviewed
• [Journal Article] M. Anthocyanidins-enriched bilberry extracts inhibit 3T3-L1 adipocyte differentiation via the insulin pathway (2011)
  • Author(s): Suzuki R., Tanaka M., Takanashi M., Hussain A., Yuan B., Toyoda H., Kuroda
  • Journal Title: Nutrition & metabolism Volume: 8(14)
  • DOI: 10.1186/1743-7075-8-14
  • Peer Reviewed
• [Presentation] 新規核酸を用いた血管新生網膜症に対する分子標的治療薬 (2013)
  • Author(s): 高梨正勝, 須藤カツ子, 松永芳径, 石川章夫, 大木忠明, 濱崎智洋, 後藤浩, 黒田雅彦
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: 札幌
  • Year and Date: 20130606-08
• [Presentation] Systemically injected exosomes targeted to EGFR deliver anti-tumor microRNA to breast cancer cells (2013)
  • Author(s): Ohno S, Takanashi M, Ohgi T, Mizutani T, Murakami T, Kuroda M.
  • Organizer: Keystones Symposia Conference-Noncording RNAs in Development and cancer
  • Place of Presentation: Vancouver, CANADA
  • Year and Date: 20130120-25
• [Presentation] Wapl regulates HP1 expression and levels of various histone H3 tail modification (2012)
  • Author(s): Oikawa K, Takanashi M, Niwa M, Sun Y, Gui T, Shimokado A, Itoh S, Ozaki T, Kuroda M, Muragaki Y
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 20121211-14
• [Presentation] マウスに経口投与したエクソソームの生体内での安定性と分布 (2012)
  • Author(s): 高梨正勝, 須藤カツ子, 大野慎一郎, 上田しのぶ, 石川章夫, 黒田雅彦
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 20120919-21
• [Presentation] 粘膜型脂肪肉腫においてTLS-CHOPは抗がん性サイトカインMDA-7/IL-24の発現を抑制する (2012)
  • Author(s): 及川恒輔, 高梨正勝, 黒田雅彦, 村垣泰光
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 20120919-21
• [Presentation] (2012)
  • Author(s): 高梨正勝, 須藤カツ子, 松永芳径, 大木忠明, 濱崎智洋, 谷口維紹, 臼井嘉彦, 後藤浩, 黒田雅彦
  • Organizer: 第32回日本眼薬理学会総会
  • Place of Presentation: 滋賀
  • Year and Date: 20120915-16
• [Presentation] 新規核酸を用いた血管新生網膜症に対する分子標的治療法の開発 (2012)
  • Author(s): 高梨正勝, 須藤カツ子松, 永芳径, 石川章夫, 大木忠明, 濱崎智洋, 後藤浩, 黒田雅彦
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: 札幌
  • Year and Date: 20120606-08
• [Presentation] T. LS-CHOP癌遺伝子が発現制御するmiRNAの解析 (2012)
  • Author(s): 那日蘇, 大野慎一郎, 田中正視, 呉偉紅, 田中理英子, 藤田浩司, 高梨正勝, 黒田雅彦
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 20120426-28
• [Presentation] 胃低分化癌におけるin situ hybridization法を用いたmiR-92aおよびmiR-200cの発現低下の意義 (2012)
  • Author(s): 倉田厚, 呉偉紅, 山田正俊, 那日蘇, 藤田浩司, 大野慎一郎, 高梨正勝, 黒田雅彦
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 20120426-28
• [Presentation] C. D63-GFPを発現したエクソソームのマウス生体内での安定性と分布について (2011)
  • Author(s): 高梨正勝, 須藤カツ子, 大野慎一郎, 上田しのぶ, 石川章夫, 黒田雅彦
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 20111003-05
• [Presentation] 人工型exosomeの生体分布と安定性についての研究 (2011)
  • Author(s): 高梨正勝, 須藤カツ子, 大野慎一郎, 上田しのぶ, 石川章夫, 黒田雅彦
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
  • Year and Date: 20110428-30