2013 Fiscal Year Final Research Report
Analyses of molecular bases by LMP-1 and CD30, which mediate transformation of lymphocytes to Hodgkin lymphoma cells
| Project/Area Number |
23590433
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | ホジキンリンパ腫 / EBウイルス / LMP-1 / JunB / CD30 |
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| Research Abstract |
Recent studies indicated that Hodgkin lymphoma (HL) cells derive mostly from B cells and very rarely from T cells. However it is unclear how normal lymphocytes transform and acquire molecular bases characteristic for HL. Epstein-Barr virus (EBV) infection is found in about half of HL cases, thereby thought to be an important mediator of the transformation. I n this study, We indicated EBV infection triggers expression of LMP-1, which mediates activation of CD30-ERK1/2-Ets-1-JunB-CD30 and CD30-NF-kB-CD40- NF-kB. The results indicate important roles of EBV for acquirement of biological bases of HL.
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Research Products
(26 results)
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[Journal Article] Incidence and Clinical Significance of Aberrant T-Cell Marker Expression on Diffuse Large B-Cell Lymphoma Cells2013
Author(s)
Suzuki Y, Yoshida T, Wang G, Aoki T, Katayama T, Miyamoto S, Miyazaki K, Iwabuchi K, Danbara M, Nakayama M, Horie R, Nakamine H, Sato Y, Nakamura N, Niitsu N
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Journal Title
Acta Haematol
Volume: 130
Pages: 230-237
DOI
Peer Reviewed
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[Journal Article] Association of CD20 levels with clinicopathological parameters and its prognostic significance for patients with DLBCL2012
Author(s)
Suzuki Y, Yoshida T, Wang G, Togano T, Miyamoto S, Miyazaki K, Iwabuchi K, Nakayama M, Horie R, Niitsu N, Sato Y, Nakamura N
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Journal Title
Ann Hematol
Volume: 91(7)
Pages: 997-1005
DOI
Peer Reviewed
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[Journal Article] Re-appearance of hepatitis B virus following therapy with rituximab for lymphoma is not rare in Japanese patients with past hepatitis B virus infection2011
Author(s)
Watanabe M, Shibuya A, Tsunoda Y, Danbara M, Ishii R, Ohsaka M, Takada J, Tanaka Y, Okuwaki Y, Minamino T, Hidaka H, Nakazawa T, Horie R, Higashihara M, Koizumi W
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Journal Title
Liver Int.
Volume: 31(3)
Pages: 340-7
DOI
Peer Reviewed
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[Presentation] The regulation of ''inflammatory niche'' with tumor derived small RNAs2013
Author(s)
山川奈津子, 横山和明, Jun Lu, 今留謙一, 渡辺俊樹, 堀江良一, 穂積勝人, 八幡崇, 安藤潔, 中村直哉, 幸谷愛
Organizer
第75回日本血液学会学術集会
Place of Presentation
札幌
Year and Date
2013-10-11
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