2013 Fiscal Year Final Research Report
Development of clinical applications for cancer/stem-cell-associated molecules target therapy in head and neck cancer
| Project/Area Number |
23590439
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
MORI TAISUKE 独立行政法人国立がん研究センター, 中央病院, 医員 (00296708)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 診断病理学 / 頭頸部がん |
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| Research Abstract |
I've been clear that the stem cell-associated molecules YBX1, Bmi1, HMGA2, and EpCAM are involved in the trait of head and neck cancer from the comprehensive analysis with a focus on related molecules in stem cells of head and neck squamous cell carcinoma.
In particular, I revealed that HMGA2 is a prognostic factor estimation and advanced cancer and that Bmi1 is a marker of early squamous cell carcinoma. Moreover,YBX1 is one of the causes of chemoradiation-resistant cancer was suggested.
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[Journal Article] Stem cell self-renewal factors, Bmi1 and HMGA2 expressed in head and neck squamous cell carcinoma : Clues to the tumor characteristics for diagnosis2013
Author(s)
Yamazaki H, Mori T, Yazawa M, Maeshima A, Matsumoto F, Yoshimoto S, Ota Y, Kaneko A, Tsuda H, Kanai Y
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Journal Title
Lab. Invest.
Volume: 93
Pages: 1331-1338
Peer Reviewed
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[Journal Article] Sox10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors : A clue to the histogenesis for diagnosis2013
Author(s)
Ohtomo R, Mori T, Shibata S, Tsuta K, Maeshima A, Akazawa C, WatabeY, Honda K, Yamada T, Yoshimoto S, Asai M, Okano H, Kanai Y, Tsuda H
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Journal Title
Mod Pathol.
Volume: 26
Pages: 1041-50
Peer Reviewed
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[Journal Article] Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms2013
Author(s)
Nishikawa G, Sekine S, Ogawa R, Matsubara A, Mori T, Taniguchi H, Kushima R, Hiraoka N, Tsuta K, Tsuda H, Kanai Y
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Journal Title
Br J Cancer
Volume: 5;108 (4)
Pages: 951-8
Peer Reviewed
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[Journal Article] Histopathological characteristics of hypervascular cholangiocellular carcinoma as an early stage of cholangiocellular carcinoma2013
Author(s)
Sato Y, Ojima H, Onaya H, Mori T, Hiraoka N, Kishi Y, Nara S, Esaki M, Shimada K, Kosuge T, Sugihara K, Kanai Y
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Journal Title
Hepatol Res.
Volume: 1;319(1)
Pages: 35-44
Peer Reviewed
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[Journal Article] Identification by Differential Tissue Proteome Analysis of Talin-1 as a Novel Molecular Marker of Progression of Hepatocellular Carcinoma2011
Author(s)
Kanamori H, Kawakami T, Effendi K, Yamazaki K, Mori T, Ebinuma H, Masugi Y, Du W, Nagasaka K, Ogiwara A, Kyono Y, Tanabe M, Saito H, Hibi T, Sakamoto M
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Journal Title
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