2013 Fiscal Year Final Research Report
Identification of HOX gene which suppresses hepatic metastasis of colon cancer
| Project/Area Number |
23590451
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
HAMADA Jun-ichi 北海道大学, 遺伝子病制御研究所, 准教授 (50192703)
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| Co-Investigator(Renkei-kenkyūsha) |
IIZASA Hisashi 北海道大学, 遺伝子病制御研究所, 助教 (80306662)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 転移 / HOX / 浸潤 / 大腸癌 |
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| Research Abstract |
In this study, we examined the roles of HOXD8 in three steps of hepatic metastasis of human colon cancer to demonstrate anti-metastatic function of HOXD8. We found the following: the cells highly invasive of subendothelial basement membrane showed higher expressions of HOXD8 than those weakly invasive; there was no correlation between adhesiveness of the cells to hepatic sinusoidal endothelial cells and the expression levels of HOXD8; the cells growing in the liver of nude mice expressed HOXD8 at higher levels than those growing in the cecum. These results suggested that HOXD8 functioned as a metastasis-enhancing or –suppressive gene depending on the step where the cells were during hepatic metastasis.
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