Role of miRNA on tumor-stromal interaction in the pancreas

2014 Fiscal Year Final Research Report

• Project/Area Number: 23590469
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Nagoya City University
• Principal Investigator: FUKAMACHI Katsumi 名古屋市立大学, 医学(系)研究科(研究院), 講師 (90381798)
• Co-Investigator(Renkei-kenkyūsha): TSUDA Hiroyuki 名古屋市立大学, その他部局, 教授 (10163809)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 膵癌

Outline of Final Research Achievements

Pancreatic ductal adenocarcinoma is an extreamly stroma-rich and highly aggressive solid tumor. We established an animal model for human pancreatic ductal adenocarcinoma using transgenic rats in which expression of a human KRAS oncogene is regulated by the Cre/loxP system. Using this model, we searched for candidate extracellular miRNAs for participating in the stroma formation in pancreatic cancer. Many miRNAs showed different expression patterns between tumor tissue and serum of rats bearing pancreatic ductal adenocrcinoma. It is suggest that the some kind of sorted miRNAs were secreted to extracellular. These miRNA might be involved in the stroma formation.

Free Research Field

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