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2013 Fiscal Year Final Research Report

Identification and the elucidation of the mechanism of interleukin 18 induced metastasis inhibitory factor(s)

Research Project

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Project/Area Number 23590480
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Experimental pathology
Research InstitutionHyogo Medical University

Principal Investigator

YAMADA Naoko  兵庫医科大学, 医学部, 講師 (10319858)

Co-Investigator(Kenkyū-buntansha) TERADA Nobuyuki  兵庫医科大学, 医学部, 名誉教授 (50150339)
NAKASHO Keiji  兵庫医科大学, 医学部, 教授 (00217712)
OHYAMA Hideki  兵庫医科大学, 医学部, 准教授 (90280685)
YAMANEGI Koji  兵庫医科大学, 医学部, 講師 (00434944)
Project Period (FY) 2011 – 2013
Keywordsインターロイキン18 / 転移 / 骨肉腫
Research Abstract

We showed the possibility of the presence of IL-18-induced metastasis inhibitory factor(s) in the previous paper. The purpose of this research is to identify the factor(s) and to clarify its metastasis suppression mechanism. We revealed that this factor mainly existed in serum. We found 32 candidates of the factor(s) using the antibody arrays. As a result of investigating the metastasis suppressing activity of five factors with high expression level, three of them inhibited the tumor cell invasion. Further, we found 42 candidates of the factor(s) through two-dimensional electrophoresis and the MALDI-TOF-MS.

  • Research Products

    (12 results)

All 2013 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (7 results)

  • [Journal Article] Decreased expression of VE-cadherin and claudin-5 and increased phosphorylation of VE-cadherin in vascular endothelium in nasal polyps2013

    • Author(s)
      Yukitatsu Y, Hata M, Yamanegi K, Yamada N, Ohyama H, Nakasho K, Kojima Y, Oka H, Tsuzuki K, Sakagami M, Terada N
    • Journal Title

      Cell Tissue Res

      Volume: 352(3) Pages: 647-57

    • DOI

      10.1007/s00441-013-1583-0

    • Peer Reviewed
  • [Journal Article] Hypoxia downregulates the expression of cell surface MICA without increasing soluble MICA in osteosarcoma cells in a HIF-1α-dependent manner2012

    • Author(s)
      Yamada N, Yamanegi K, Ohyama H, Hata M, Nakasho K, Futani H, Okamura H, Terada N
    • Journal Title

      Int J Oncol

      Volume: 41(6) Pages: 2005-12

    • DOI

      10.3892/ijo.2012.1630

    • Peer Reviewed
  • [Journal Article] Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells2012

    • Author(s)
      Yamanegi K, Yamane J, Kobayashi K, Ohyama H, Nakasho K, Yamada N, Hata M, Fukunaga S, Futani H, Okamura H, Terada N
    • Journal Title

      Oncol Rep

      Volume: 28(5) Pages: 1585-90

    • DOI

      10.3892/or.2012.1981

    • Peer Reviewed
  • [Journal Article] Valproic acid cooperates with hydralazine to augment the susceptibility of human osteosarcoma cells to Fas- and NK cell-mediated cell death2012

    • Author(s)
      Yamanegi K, Yamane J, Kobayashi K, Kato-Kogoe N, Ohyama H, Nakasho K, Yamada N, Hata M, Fukunaga S, Futani H, Okamura H, Terada N
    • Journal Title

      Int J Oncol

      Volume: 41(1) Pages: 83-91

    • DOI

      10.3892/ijo.2012.1438

    • Peer Reviewed
  • [Journal Article] The promotional effect of IL-22 on mineralization activity of periodontal ligament cells2012

    • Author(s)
      Kato-Kogoe N, Nishioka T, Kawabe M, Kataoka F, Yamanegi K, Yamada N, Hata M, Yamamoto T, Nakasho K, Urade M, Terada N, Ohyama H
    • Journal Title

      Cytokine

      Volume: 59(1) Pages: 41-8

    • DOI

      10.1016/j.cyto.2012.03.024

    • Peer Reviewed
  • [Presentation] 低酸素による細胞表面MICAの糖鎖修飾の低下2013

    • Author(s)
      山田直子、山根木康嗣、大山秀樹、寺田信行、中正恵二
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸
    • Year and Date
      2013-12-03
  • [Presentation] 骨肉腫細胞における低酸素誘導性の細胞表面MICAの発現低下2012

    • Author(s)
      山田直子、山根木康嗣、大山秀樹、中正恵二、秦正樹、寺田信行
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Year and Date
      20121211-14
  • [Presentation] ヒストン脱アセチル化阻害剤を用いた腫瘍血管新生抑制2012

    • Author(s)
      山根木康嗣、小林健太、中正恵二、大秀樹、山田直子、秦正樹、寺田信行
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      20120426-28
  • [Presentation] Th17細胞産生性サイトカインが血管石灰化に及ぼす影響2012

    • Author(s)
      大山秀樹、片岡芙紗、川辺睦記、小越菜保子、山根木康嗣、山田直子、秦正樹、中正恵二、寺田信行
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      20120426-28
  • [Presentation] Epigenetic drugによるヒト骨肉腫細胞の抗腫瘍免疫細胞に対する感受性亢進2011

    • Author(s)
      山根木康嗣、小林健太、大山秀樹、秦正樹、山田直子、中正恵二、寺田信行
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      20110428-30
  • [Presentation] IL12RB2転写活性の個体差におけるAP-1ファミリー転写因子の関与2011

    • Author(s)
      大山秀樹、小越菜保子、山根木康嗣、山田直子、秦正樹、片岡芙紗、中正恵二、寺田信行
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      20110428-30
  • [Presentation] 骨肉腫に対するIL-18とイホマイドの併用療法の可能性2011

    • Author(s)
      山田直子、秦正樹、山根木康嗣、大山秀樹、中正恵二、麩谷博之、岡村春樹、寺田信行
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14

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Published: 2015-07-16   Modified: 2016-01-05  

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