2013 Fiscal Year Final Research Report
Animal model for the treatment of Chronic Chagas Disease using the combination of drug and vaccine
| Project/Area Number |
23590486
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Nagasaki University |
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Principal Investigator |
HIRAYAMA Kenji 長崎大学, 熱帯医学研究所, 教授 (60189868)
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| Co-Investigator(Kenkyū-buntansha) |
KIKUCHI Mihoko 長崎大学, 熱帯医学研究所, 講師 (40336186)
MOHAMMED NASIR Shuaibu 長崎大学, 熱帯医学研究所, 助教 (30535745)
YANAGI Tetsuo 長崎大学, 熱帯医学研究所, 助手 (10174541)
UEMURA Haruki 長崎大学, 熱帯医学研究所, 講師 (60184975)
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| Project Period (FY) |
2011 – 2013
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| Keywords | シャーガス病 / ワクチン / 慢性感染症 / ベンズニダゾール / 遺伝子導入原虫 / 画像解析 / ＤＮＡワクチン / ナノテクノロジー |
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| Research Abstract |
To find a new strategy to treat a chronic Chagas adult patient, we tried to establish a chronic infection model with mouse and luciferase gene transfected Y strain of Trypanosoma cruzi and successfully obtain a protocol to observe the chronic status using whole body imaging system. Then we prepared the DNA vaccine using previously reported three candidate genes namely TcG1, TcG2 and Tcg4 and our recently established pVAX 200DEST nano-particle adjuvant to observe that effect on the elimination of chronically infected parasites. The evaluation of the vaccines has not yet finished but the vaccination could provoke substantial immunological effect by B and T cell levels.
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Research Products
(16 results)
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[Journal Article] Protective Human Leucocyte Antigen Haplotype, HLA-DRB1*01-B*14, against Chronic Chagas Disease in Bolivia2012
Author(s)
Del Puerto F, Nishizawa JE, Kikuchi M, Roca Y, Avilas C, Gianella A, Lora J, Velarde FU, Miura S, Komiya N, Maemura K, Hirayama K
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Journal Title
PLoS Negl Trop Dis
Volume: 6(3), (Published online)
Pages: e1587
DOI
Peer Reviewed
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[Presentation] Immunogenetic analysis of chronic Chagas disease in Bolivia2011
Author(s)
Florencia del Puerto Rodas, Juan Eiki Nishizawa, Mihoko Kikuchi, Naomi Iihoshi, Yelin Raca, Cinthia Avilas, Alberto Gianella, Javier Lora, Freddy Udalrico. Gutierrez. Velarde, Luis Alberto. Renjel, Sachio Miura, Hiroo Higo, Norihiro Komita. Kouji Maemura, Michio Yasunami, and Kenji Hirayama
Organizer
第20回日本組織適合性学会大会
Place of Presentation
ツインメッセ静岡北館および中央棟、静岡日本組織適合性学会誌MHC、Vol. 18 No. 2, 2011、pp152. 2011)
Year and Date
20110828-30
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