Development of predictive model for future prevalence of antimalarial-resistant gene using microsatellite polymorphism

2014 Fiscal Year Final Research Report

• Project/Area Number: 23590498
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Parasitology (including Sanitary zoology)
• Research Institution: Juntendo University (2012-2014); Tokyo Women's Medical University (2011)
• Principal Investigator: Mita Toshihiro 順天堂大学, 医学(系)研究科(研究院), 教授 (80318013)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: マラリア / 薬剤耐性 / 耐性遺伝子 / 予測モデル

Outline of Final Research Achievements

Malaria is one of the three major infectious disease including tuberculosis and HIV/AIDS. The biggest barrier for the global achievement of malaria control is emergence and spread of drug resistant malaria. This study successfully created a model that can estimate a level of selective advantage in drug-resistant parasite by one-point sampling and by using this estimate, predict the trajectory of drug resistant allele prevalence. This model will be able to be applicable to various malaria endemic regions and provide future estimation of drug-resistance without frequent sampling.

Free Research Field

熱帯医学