2013 Fiscal Year Final Research Report
Sample Helicobacter Pylori
| Project/Area Number |
23590518
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Shinichi 杏林大学, 医学部, 教授 (10137953)
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| Co-Investigator(Renkei-kenkyūsha) |
OSAKI Takako 杏林大学, 医学部, 准教授 (90255406)
HANAWA Tomoko 杏林大学, 医学部, 講師 (80255405)
YONEZAWA Hideo 杏林大学, 医学部, 講師 (60453528)
KURATA Satoshi 杏林大学, 医学部, 学内講師 (00383670)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ヘリコバクター・ピロリ / 胃粘膜 / フローラ / T-RFLP / 胃炎 / 胃癌 |
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| Research Abstract |
Correlation between Helicobacter pylori and gastric microbiota was examined for the patients with chronic gastritis and gastric cancer. It was shown that streptococci were dominant in the patients with gastritis regardless of H. pylori infection and that Atopobacterium, Enterococcus and Lactobacillus were detected only in the H. pylori positive gastritis patients. Gastric microbiota of the patient with gastric cancer was similar to that of H. pylori-negative gastritis patients. By meta-genome analysis, it was shown that Neisseriaceae, Burkholderiaceae and Enterobacteiaceae, Pseudomonadaceae were dominant Proteobacteria for the H. pylori positive and negative patients with gastritis, respectively. These results suggest that H. pylori infection affects gastric environments for persistence of other gastric microbiota by decreasing of gastric acidity.
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[Journal Article] Development of a PCR method for the detection of Helicobacter suis in gastric biopsy specimens2014
Author(s)
Matsui H, Takahashi T, Yamagata-Murayama S, Uchiyama I, Yamaguchi K, Shigenobu S, Matsumoto T, Kawakubo M, Ota H, Osaki T, Kamiya S, Takahashi S, Nakamura S, Nakamura M
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Journal Title
Helicobacter
Volume: (in press), (Epub ahead of print)
DOI
Peer Reviewed
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[Journal Article] Multi locus sequence typing for the analysis of intra-familial transmission of Helicobacter pylori by using feacal specimens2013
Author(s)
Osaki T, Okuda M, Ueda J, Konno M, Yonezawa H, Hojo F, Yagyu K, Lin Y, Fukuda Y, Kikuchi S, Kamiya S
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Journal Title
J Med Microbiol
Volume: 62(5)
Pages: 761-765
DOI
Peer Reviewed
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[Journal Article] Anacardic acid, a histone acetyltransferase inhibitor, modulates LPS-induced IL-8 expression in a human alveolar epithelial cell line A5492013
Author(s)
Yasutake T, Wada H, Higaki M, Nakamura M, Honda K, Watanabe M, Ishii H, Kamiya S, Takizawa H, Goto H
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Journal Title
F1000Res
Volume: 2, (2-78. v1. eCollection 2013)
Pages: 78
DOI
Peer Reviewed
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[Journal Article] Ciliates Expel Legionella-laden Pellets for Stockpiling Food2012
Author(s)
Hojo F, Sato D, Goto M, Matsuo J, Nakamura S, Hayashi Y, Konuma M, Sakai H, Yoshida M, Takahashi K, Takemura H, Kamiya S, Yamaguchi H.
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Journal Title
Applied Environment Microbiol
Volume: 78(15)
Pages: 5247-5257
DOI
Peer Reviewed
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[Journal Article] Destructive effects of butyrate on cell envelope of Helicobacter pylori2012
Author(s)
Yonezawa H, Osaki T, Hanawa T, Kurata S, Zaman C, Woo TDH, Takahashi M, Mastubara S, Kawakami H, Ochiai K, Kamiya S
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Journal Title
J Med Microbiol
Volume: 61(4)
Pages: 582-589
DOI
Peer Reviewed
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[Journal Article] Attenuated CagA oncoprotein in Helicobacter pylori from Amerindians in Peruvian Amazon2011
Author(s)
Suzuki M, Kiga K, Dersulyte D, Cok J, Hooper CC, Mimuro H, Sanada T, Suzuki S, Oyama M, Kozuka-Hata H, Kamiya S, Zou Q-M, Gilman RH, Berg DE, Sasakawa C
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Journal Title
J Biol Chem
Volume: 286(34)
Pages: 29964-29972
DOI
Peer Reviewed
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