2013 Fiscal Year Final Research Report
Exploration of the optimal biomarkers reflecting each stage of atherosclerotic progression in patients with diabetes mellitus
| Project/Area Number |
23590661
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Masami 群馬大学, 医学(系)研究科(研究院), 教授 (30241871)
KURABAYASHI Masahiko 群馬大学, 医学(系)研究科(研究院), 教授 (00215047)
NAKAHARA Takehiro 群馬大学, 医学部附属病院, 助教 (00599540)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 内科学 / 臨床検査医学 / 動脈硬化 / 生理機能 / バイオマーカー |
|---|
| Research Abstract |
Each stage of atherosclerotic progression can be evaluated based on the results of three clinical vascular atherosclerosis-evaluating tests. In the initial stage, there is a low flow-mediated vasodilation level. In the intermediate atherosclerotic formation stage, there is a high cardioankle vascular index level. Finally, in the intima-media thickening stage, there is a high intima-media thickness level. To explore the optimal biomarkers reflecting each stage of atherosclerotic progression, these three tests and circulating biomarker measurements were performed in patients with lifestyle-related diseases, including diabetes mellitus. Each stage of atherosclerotic progression in subjects with lifestyle-related diseases, including diabetes, may reflect the initial stage if the uric acid or LDL-C level is high, the intermediate stage if the ICAM-1 level is high and the BAP or NOx level is low, and the intima-media thickening stage if the ICAM-1 level is high.
|
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 血清中アポリポ蛋白M測定の臨床的意義の検討2013
Author(s)
木村孝穂, 角野博之, 荒木修, 常川勝彦, 青木智之, 荻原貴之, 奈良誠人, 町田哲男, 桑原敦志, 岡島史和, 村上正巳
Organizer
第60回日本臨床検査医学会学術集会
Place of Presentation
神戸国際会議場
Year and Date
2013-11-02
-
-
-
-
-
[Presentation] Tuberculosis screening by a T cell interferon-γrelease assay in students of medical school and international students in Gunma University2012
Author(s)
Rumi Watanabe, Takao Kimura, Yutaka Tokue, Takayuki Ogiwara, Makoto Nara, Yoshino Kobayashi, Toshiya Inoue, Hiroyuki Sumino, Tadashi Morimura, Osamu Araki, Katsuhiko Tsunekawa, Tomoyuki Aoki, Toshiko Obuchi, Yukie Yomoda, Kihachi Ohshima, Masami Murakami
Organizer
12回アジア臨床病理・臨床検査医学会
Place of Presentation
国立京都国際会館
Year and Date
2012-12-01
-
[Presentation] 生活習慣病患者及び健常ボランティアにおける血液レオロジーと血管内皮機能との関係2012
Author(s)
角野博之, 青木智之, 常川勝彦, 森村匡志, 荒木修, 木村孝穂, 奈良誠人, 荻原貴之, 町田哲男, 四方田幸恵, 村上正巳
Organizer
第59回日本臨床検査医学会学術集会
Place of Presentation
国立京都国際会館
Year and Date
2012-12-01
-
-
-
[Presentation] 中高年男性における内因性の血中男性ホルモン濃度と冠動脈疾患との関係2011
Author(s)
角野博之, 青木智之, 常川勝彦, 森村匡志, 荒木修, 木村孝穂, 荻原貴之, 奈良誠人, 古田島伸雄, 町田哲男, 四方田幸恵, 村上正巳
Organizer
第58回日本臨床検査医学会学術集会
Place of Presentation
岡山コンベンションセンター
Year and Date
2011-11-18
-
-
-
-
