2014 Fiscal Year Final Research Report
Clinical significance of measuring lipolytic enzyme for predicting non-alcoholic steato hepatitis
| Project/Area Number |
23590663
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kanazawa Medical University (2012-2014)
Kanazawa University (2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKADA Toshihide 金沢大学, 医学系, 特任教授 (20251944)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 肝性リパーゼ / 非アルコール性脂肪肝炎 |
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| Outline of Final Research Achievements |
We investigated whether hepatic lipase in post-heparin plasma could be a useful marker for diagnosing non-alcoholic steato hepatitis (NASH).Forty-two Argentines and thirty-one Japanese patients were involved in this study.
In Argentines, steatosis grade were classified into 3 grades and there were no significant differences in HL activities among the three groups. In Japanese patients, there was no difference in HL activities between subjects with and without NASH. These findings suggest that there is a limitation of applying HL activity as a method of reflecting HL. Alternatively we established a new enzyme-linked immunosorbent assay system for human HL protein mass. The correlation coefficients between alanine aminotransferase (ALT) and HL activity was 0.185(p<0.05) whereas those between ALT and HL mass was (0.285 p<0.01). This suggest that HL mass is superior to HL activity for detecting NASH.
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| Free Research Field |
臨床検査学
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