2013 Fiscal Year Final Research Report
Clinicopathological study on adenocarcinoma of gastric phenotype and its precursor lesion
| Project/Area Number |
23590664
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKUMURA Nobuo 信州大学, 医学部, 教授 (60252110)
HONDA Takayuki 信州大学, 医学部, 教授 (80238815)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 膵管内乳頭粘液性腫瘍 / 膵腫瘍 / 粘液 |
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| Research Abstract |
Pancreatic intraductal papillary mucinous neoplasms (IPMNs) are mucin-producing
neoplasms of the main and/or branch pancreatic ducts. To assess differences between various IPMN subtypes, immunohistochemical markers of gastrointestinal cells were evaluated in 33 surgically treated IPMNs. IPMNs into gastric (n=17), intestinal (n=8) and mixed gastric and intestinal type (collision=7, composite=1). No differences in age or sex were observed among these types. Gastric pyloric and small intestinal differentiation are characteristic of gastric and intestinal type IPMN, respectively, and these two IPMN types may have distinct pathogenesis.
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