2013 Fiscal Year Final Research Report
Prevention of the onset of Graves' disease using high sensitivity method for TSH receptor antibody
| Project/Area Number |
23590671
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Osaka University |
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Principal Investigator |
HIDAKA YOH 大阪大学, 医学(系)研究科(研究院), 准教授 (30243231)
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| Project Period (FY) |
2011 – 2013
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| Keywords | バセドウ病 / TSHレセプター抗体 |
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| Research Abstract |
We examined the correlation between the levels of TSH receptor antibody (TRAb) and cytokines in the supernatant incubated with the peripheral blood mononuclear cells (PBMCs) from the patients with Graves' disease in order to analyze the mechanism of onset of Graves' disease. However we could not find the correlation between the level of TRAb and cytokines.
We tried to find the drugs that could suppress the production of TRAb in order to prevent the onset of Graves' disease. However the production of TRAb was not suppressed by anti-thyroid drug (methimazol) and anti-CD20 monoclonal antibody (rituximab).
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Research Products
(30 results)
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[Journal Article] Pseudohypoglycemia or hyperglycemia caused by interference with self-monitoring blood glucose measurements in anticancer ascorbic acid therapy2013
Author(s)
Kimura T, Kozawa J, Matsui M, Nishizawa H, Yasuda T, Otsuki M, Iwahashi H, Kaneto H, Funahashi T, Hidaka Y, Imagawa A, Shimomura I
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Journal Title
Journal of Diabetes Investigation
Volume: 4(6)
Pages: 679-680
DOI
Peer Reviewed
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[Journal Article] Genes that characterize T3-predominant Graves' thyroid tissues2013
Author(s)
Matsumoto C, Ito M, Yamada H, Yamakawa N, Yoshida H, Date A, Watanabe M, Hidaka Y, Iwatani Y, Miyauchi A, Takano T
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Journal Title
Eur J Endocrinol
Volume: 168(2)
Pages: 137-144
DOI
Peer Reviewed
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[Journal Article] Associations between autoimmune thyroid disease prognosis and functional polymorphisms of susceptibility genes, CTLA4, PTPN22, CD40, FCRL3, and ZFAT, previously revealed in Genome-wide association studies2012
Author(s)
Inoue N, Watanabe M, Yamada H, Takemura K, Hayashi F, Yamakawa N, Akahane M, Shimizuishi Y, Hidaka Y, Iwatani Y
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Journal Title
J Clin Immunol
Volume: 32(6)
Pages: 1243-1252
DOI
Peer Reviewed
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[Journal Article] Thyroid Function Influences Serum Apolipoprotein B-48 Levels in Patients with Thyroid Disease2012
Author(s)
Mugii S, Hanada H, Okubo M, Masuda D, Takeoka K, Hidaka Y, Ohama T, Matsuyama A, Nakagawa-Toyama Y, Nishida M, Ishigami M, Komuro I, Yamashita S
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Journal Title
J Atheroscler Thromb
Volume: 19(10)
Pages: 890-896
URL
Peer Reviewed
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[Presentation] 妊娠初期に投与されたチアマゾールの妊娠結果に与える影響に関する前向き研究(POEMスタディ):中間報告2011
Author(s)
荒田尚子, 村島温子, 伊藤真也, 大橋靖雄, 小野瀬裕之, 窪田純久, 田尻淳一, 浜田昇, 日高洋, 深田修司, 百渓尚子, 小崎健次郎, 小崎里華, 吉川裕之
Organizer
日本甲状腺学会第54回
Place of Presentation
大阪
Year and Date
2011-11-23
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[Book] バセドウ病治療ガイドライン20112011
Author(s)
阿部好文, 網野信行, 飯高誠, 伊藤公一, 岡村建, 小澤安則, 上條桂一, 窪田純久, 佐々木純, 紫芝良昌, 田尻淳一, 田中祐司, 對馬敏夫, 中村浩淑, 浜田昇, 日高洋, 深田修司, 三橋知明, 宮内昭, 百渓尚子, 吉村弘, 内村英正, 岡本泰之, 小西淳二, 中駄邦博, 野口靖志, 御前隆
Publisher
南江堂
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