Study of lipid-related markers for nutritional assessment unaffected by inflammation

2013 Fiscal Year Final Research Report

• Project/Area Number: 23590689
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Juntendo University
• Principal Investigator: MIIDA Takashi 順天堂大学, 医学(系)研究科(研究院), 教授 (80260545)
• Co-Investigator(Kenkyū-buntansha): HIRAYAMA Satoshi 順天堂大学, 医学部, 准教授 (10345506) ; NAKAGAWA Saori 新潟薬科大学, 薬学部, 助教 (30410228) ; YAMATO Susumu 新潟薬科大学, 薬学部, 教授 (60057370)
• Project Period (FY): 2011 – 2013
• Keywords: 栄養学 / 脂質 / 臨床 / 炎症

Research Abstract

Nutrition support team (NST) assesses nutritional state of malnourished patients for nutritional intervention as well as evaluation of its effectiveness. Clinically, many variables such as albumin, total cholesterol (TC), transthyretin (TTR), retinol binding protein (RBP), and transferrin (Tf). Among them, TTR, RBP, and Tf are known as rapid turnover proteins because their half lives are only within a few days in human plasma. However, they decrease markedly in inflammation. This study clearly demonstrates that (1) serum albumin decreases in inflammation but albumin concentrations measured by bromocresol green (BCG) method exhibits positive bias, (2) LDL-C reflects cholesterol absorption in the small intestine rather than de novo cholesterol synthesis in the liver, and (3) LDL-C does not decrease in the patients with inflammation. These results strongly suggest that LDL-C may enable us to evaluate nutritional state more precisely free of influence from inflammation. (664)

Research Products

• [Journal Article] Validation of homogeneous assays for HDL- cholesterol using fresh samples from healthy and diseased subjects (2014)
  • Author(s): Miida T, Nishimura K, Okamura T, Hirayama S, Ohmura H, Yoshida H, Miyashita Y, Ai M, Tanaka A, Sumino H, Murakami M, Inoue I, Kayamori Y, Nakamura M, Nobori T, Miyazawa Y, Teramoto T, Yokoyama S
  • Journal Title: Atherosclerosis Volume: 233 (1) Pages: 253-9
  • DOI: 10.1016/j.atherosclerosis.2013.12.033
  • Peer Reviewed
• [Journal Article] Selective evaluation of high density lipoprotein from mouse small intestines by an in situ perfusion technique (2014)
  • Author(s): Yamaguchi S, Zhang B, Tomonaga T, Seino U, Kanagawa A, Nagasaka H, Suzuki A, Miida T, Yamada S, Sasaguri Y, Doi T, Saku K, Okazaki M, Tochino Y, Hirano K
  • Journal Title: J Lipid Res Volume: 55 (5) Pages: 905-18
  • DOI: 10.1194/jlr.M047761
  • Peer Reviewed
• [Journal Article] The mean postprandial triglyceride concentration is an independent risk factor of carotid atherosclerosis in patients with type 2 diabetes (2014)
  • Author(s): Idei M, Hirayama S, Miyake N, Kon M, Horiuchi Y, Ueno T, Miyake K, Sato N, Yoshii H, Yamashiro K, Onuma T, Miida T
  • Journal Title: Clin Chim Acta Volume: 430 Pages: 134-9
  • DOI: 10.1016/j.cca.2013.12.022
  • Peer Reviewed
• [Journal Article] High-density lipoprotein levels have markedly increased over the past twenty years in Japan (2014)
  • Author(s): Yokoyama S, Ueshima H, Miida T, Nakamura M, Takata K, Fukukawa T, Goto T, Harada-Shiba M, Sano M, Kato K, Matsuda K
  • Journal Title: J Atheroscler Thromb Volume: 21 (2) Pages: 151-60
  • URL: https://www.jstage.jst.go.jp/article/jat/21/2/21_20909/_article
  • Peer Reviewed
• [Journal Article] Albumin concentration determined by the modified bromocresol purple method is superior to that by the bromocresol green method for assessing nutritional status in malnourished patients with inflammation (2013)
  • Author(s): Ueno T, Hirayama S, Ito M, Nishioka E, Fukushima Y, Satoh T, Idei M, Horiuchi Y, Shoji H, Ohmura H, Shimizu T, Miida T
  • Journal Title: Ann Clin Biochem Volume: 50 (6) Pages: 576-84
  • DOI: 10.1177/0004563213480137
  • Peer Reviewed
• [Journal Article] Ezetimibe decreases serum oxidized cholesterol without impairing bile acid synthesis in Japanese hypercholesterolemic patients (2013)
  • Author(s): Hirayama S, Nakagawa S, Soda S, Kamimura Y, Nishioka E, Ueno T, Fukushima Y, Higuchi K, Inoue M, Seino U, Ohmura H, Yamato S, Miida T
  • Journal Title: Atherosclerosis Volume: 230 (1) Pages: 48-51
  • DOI: 10.1016/j.atherosclerosis.2013.06.016
  • Peer Reviewed
• [Journal Article] Oxysterol changes along with cholesterol and vitamin D changes in adult phenylketonuric patients diagnosed by newborn mass-screening (2013)
  • Author(s): Nagasaka H, Okano Y, Kimura A, Mizuochi T, Yoshino M, Sanayama Y, Takatani T, Nakagawa S, Hasegawa E, Takuwa M, Hirano K, Mochizuki H, Ohura T, Sakamoto O, Ishige-Wada M, Usui H, Yorifuji T, Tsukahara H, Hirayama S, Ito T, Ohtake A, Yamato S, Miida T
  • Journal Title: Clin Chim Acta Volume: 416 Pages: 54-9
  • DOI: 10.1016/j.cca.2012.10.011
  • Peer Reviewed
• [Journal Article] A multicenter study on the precision and accuracy of homogeneous assays for LDL-cholesterol : Comparison with a beta-quantification method using fresh serum obtained from non-diseased and diseased subjects (2012)
  • Author(s): Miida T, Nishimura K, Okamura T, Hirayama S, Ohmura H, Yoshida H, Miyashita Y, Ai M, Tanaka A, Sumino H, Murakami M, Inoue I, Kayamori Y, Nakamura M, Nobori T, Miyazawa Y, Teramoto T, Yokoyama S
  • Journal Title: Atherosclerosis Volume: 225 (1) Pages: 208-15
  • DOI: 10.1016/j.atherosclerosis.2012.08.022
  • Peer Reviewed
• [Journal Article] Non-high-density lipoprotein cholesterol is a practical predictor of long-term cardiac death after coronary artery bypass grafting (2012)
  • Author(s): Fukushima Y, Ohmura H, Mokuno H, Kajimoto K, Kasai T, Hirayama S, Miyauchi K, Miida T, Amano A, Daida H
  • Journal Title: Atherosclerosis Volume: 221 (1) Pages: 206-11
  • DOI: 10.1016/j.atherosclerosis.2011.12.012
  • Peer Reviewed
• [Journal Article] Small dense LDL : An emerging risk factor for cardiovascular disease (2012)
  • Author(s): Hirayama S, Miida T
  • Journal Title: Clin Chim Acta Volume: 414 (3) Pages: 215-24
  • DOI: 10.1016/j.cca.2012.09.010
  • Peer Reviewed
• [Journal Article] CD36 deficiency predisposing young children to hypoglycemia (2011)
  • Author(s): Nagasaka H, Yorifuji T, Takatani T, Okano Y, Tsukahara H, Yanai H, Hirano KI, Hui SP, Hirayama S, Ito T, Chiba H, Miida T
  • Journal Title: Metabolism Volume: 60 (6) Pages: 881-7
  • DOI: 10.1016/j.metabol.2010.08.008
  • Peer Reviewed
• [Journal Article] Small dense LDL cholesterol is a robust therapeutic marker of statin treatment in patients with acute coronary syndrome and metabolic syndrome (2011)
  • Author(s): Fukushima Y, Hirayama S, Ueno T, Dohi T, Miyazaki T, Ohmura H, Mokuno H, Miyauchi K, Miida T, Daida H
  • Journal Title: Clin Chim Acta Volume: 412 (15-16) Pages: 1423-7
  • DOI: 10.1016/j.cca.2011.04.021
  • Peer Reviewed
• [Journal Article] Cross-sectional study of bone metabolism with nutrition in adult classical phenylketonuric patients diagnosed by neonatal screening (2011)
  • Author(s): Nagasaka H, Tsukahara H, Takatani T, Sanayama Y, Takayanagi M, Ohura T, Sakamoto O, Ito T, Wada M, Yoshino M, Ohtake A, Yorifuji T, Hirayama S, Miida T, Fujimoto H, Mochizuki H, Hattori T, Okano Y
  • Journal Title: J Bone Miner Metab Volume: 29 (6) Pages: 737-43
  • DOI: 10.1007/s00774-011-0276-6)その他7件
  • Peer Reviewed
• [Presentation] アルブミン測定法がネフローゼ症候群のアルブミン値に及ぼす影響について (2013)
  • Author(s): 上野剛, 平山哲, 昆美香, 小野塚麻里, 三井田孝
  • Organizer: 第60回日本臨床検査医学会学術集会
  • Place of Presentation: 神戸市
  • Year and Date: 20131031-1102
• [Presentation] LDL-C直接測定法における新鮮プール血清の保存安定性の検討 (2013)
  • Author(s): 平山哲, 上野剛, 昆美香, 三宅一徳, 三井田孝
  • Organizer: 第53回日本臨床化学会年次学術集会
  • Place of Presentation: 徳島市
  • Year and Date: 20130830-0901
• [Presentation] 血漿中イソプレノイドのLC-MS/ MS高感度定量 (2013)
  • Author(s): 中川沙織, 平山哲, 木村晋也, 三井田孝, 大和進
  • Organizer: 第53回日本臨床化学会年次学術集会
  • Place of Presentation: 徳島市
  • Year and Date: 20130830-0901
• [Presentation] 脂質検査のトピックス-LDL-C直接法を中心に- (2013)
  • Author(s): 三井田孝
  • Organizer: 第54回人間ドック学術大会
  • Place of Presentation: 徳島市
  • Year and Date: 20130829-30
  • Invited
• [Presentation] リポ蛋白定量の歩みと解決すべき問題点 (2013)
  • Author(s): 三井田孝
  • Organizer: 第45回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 20130718-19
  • Invited
• [Presentation] 日本人のHDLコレステロール測定値の長期上昇傾向について (2013)
  • Author(s): 横山信治, 上島弘嗣, 三井田孝, 高田耕基, 福川辰之, 五藤孝秋, 中村雅一, 斯波真理子, 佐野道孝
  • Organizer: 第45回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 20130718-19
• [Presentation] 動脈硬化性疾患予防ガイドライン(2012年版)と脂質検査 (2013)
  • Author(s): 三井田孝
  • Organizer: 第62回日本医学検査学会
  • Place of Presentation: 高松市
  • Year and Date: 20130518-19
  • Invited
• [Presentation] 周産期における糖・脂質代謝動態の変動 (2012)
  • Author(s): 平山哲, 上野剛, 西岡笑子, 松川岳久, 出居真由美, 堀内裕紀, 牧野真太郎, 北村文彦, 横山和仁, 竹田省, 三井田孝
  • Organizer: 第52回日本臨床化学会年次学術集会
  • Place of Presentation: 盛岡市
  • Year and Date: 20120906-08
• [Presentation] 冠動脈疾患におけるHDLの代謝異常:臨床的なマーカーと新しい治療手段LDL-C直接測定法の精密性および正確性の検討 (2012)
  • Author(s): 三井田孝
  • Organizer: 第44回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 20120719-20
  • Invited
• [Presentation] 冠動脈疾患におけるHDLの代謝異常:臨床的なマーカーと新しい治療手段 (2012)
  • Author(s): 三井田孝
  • Organizer: CVIT2012日本インターベンション治療学会学術集会
  • Place of Presentation: 新潟市
  • Year and Date: 20120712-14
  • Invited
• [Presentation] Friedewaldの式のLDL-Cとホモジニアス法のLDL-C (2011)
  • Author(s): 三井田孝
  • Organizer: 第58回日本臨床検査医学会学術集会(シンポジウム)
  • Place of Presentation: 岡山市
  • Year and Date: 2011-11-18
• [Presentation] Preliminary report on evaluation of LDL-cholesterol homogeneous assays–Comparison with BQ method - (2011)
  • Author(s): Miida T
  • Organizer: 2011 AACC Annual Meeting : International Lipoprotein Standardization Forum
  • Place of Presentation: Atlanta, U.S.A
  • Year and Date: 2011-07-26
  • Invited
• [Presentation] Cholesterol absorption has more close association with LDL-C concentration than cholesterol synthesis in Japanese hypercholesterolemia (2011)
  • Author(s): Hirayama S, Nakagawa S, Fukushima Y, Ueno T, Ohmura H, Higuchi K, Inoue M, Yamato S, Miida T
  • Organizer: 第43回日本動脈硬化学会総会
  • Place of Presentation: 札幌市
  • Year and Date: 2011-07-16
• [Presentation] The effects of ezetimibe on postprandial hyperlipidemia and endothelial function in patients with type IIb hyperlipidemia (2011)
  • Author(s): Fukushima Y, Ohmura H, Sato F, Hirayama S, Mokuno H, Watada H, Miida T, Daida H
  • Organizer: 第43回日本動脈硬化学会総会
  • Place of Presentation: 札幌市
  • Year and Date: 2011-07-16
• [Book] 人体の構造と機能及び疾病の成り立ち (2013)
  • Author(s): 三井田孝, 平山哲
  • Total Pages: 総ページ数341(p-163-169を分担)
  • Publisher: 南江堂
• [Book] 冠動脈疾患のパーフェクトマネジメント (2013)
  • Author(s): 三井田孝
  • Total Pages: 総ページ数233(p-89-91を分担)
  • Publisher: 南江堂
• [Book] 動脈硬化性疾患予防のための脂質異常症治療ガイド2013年版 (2013)
  • Author(s): 三井田孝
  • Total Pages: 総ページ数133 (p-111を分担)
  • Publisher: 杏林舎