2013 Fiscal Year Final Research Report
Development of high sensitivity assay for oxytocin, peptide hormone, and its clinical application utilizing aptamer
| Project/Area Number |
23590690
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ARAKAWA Hidetoshi 昭和大学, 薬学部, 教授 (70129807)
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| Project Period (FY) |
2011 – 2013
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| Keywords | アプタマー / オキシトシン / アスペルガー / 臨床分析化学 |
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| Research Abstract |
Aptamers are single strand DNA and RNA oligonucleotides binding to their target with high affinity by three-dimensional conformation of aptamers. In this study, we report development of the high sensitively assay utilizing the aptamer for oxytocin, is associated to autism spectrum. As a result, various aptamers for oxytocin were generated by using RNA and DNA on SELEX. Those aptamers for oxytocin have checked to evaluate the affinity with oxytocin.
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