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2013 Fiscal Year Final Research Report

Translational research of animal study and clinical trial for the mechanisms of weather-dependent pain aggravation.

Research Project

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Project/Area Number 23590710
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pain science
Research InstitutionNagoya University

Principal Investigator

SATO JUN  名古屋大学, 動物実験支援センター, 教授 (00235350)

Project Period (FY) 2011 – 2013
Keywords気象変化 / 慢性痛 / 自律神経 / 内耳前庭
Research Abstract

The authors have clarified underlying mechanisms of weather-sensitive diseases in the basic study with animal and subjects. In the present research project, we have further progressed the animal study and had clinical study using chronic pain patients with their pain to be sensitive to weather change. This translational study clarified important roles of inner ear in the mechanism of weather-sensitive condition and provided a scientific link between laboratory research and human trials, and the beginning of discovery of therapeutic strategies for this syndrome.

  • Research Products

    (34 results)

All 2014 2013 2012 2011

All Journal Article (10 results) (of which Peer Reviewed: 7 results) Presentation (23 results) (of which Invited: 8 results) Book (1 results)

  • [Journal Article] Activated spinal astrocytes are invol- ved in the maintenance of chronic widespread mechanical hyperalgesia after cast immobili- zation2014

    • Author(s)
      Ohmichi M, Ohmichi Y, Ohishi H, Yoshimoto T, Morimoto A, Li Y, Sakurai H, Nakano T, Sato J
    • Journal Title

      Molecular Pain

      Volume: 10(1) Pages: 6

    • DOI

      10.1186/1744-8069-10-6

    • Peer Reviewed
  • [Journal Article] 痛みと自律神経2013

    • Author(s)
      佐藤純
    • Journal Title

      自律神経

      Volume: 50巻 Pages: 226-228

  • [Journal Article] 気象痛と対策2013

    • Author(s)
      佐藤純
    • Journal Title

      臨床整形外科

      Volume: 48巻 Pages: 458-460

  • [Journal Article] The effect of celiac plexus block on hear rate variability2013

    • Author(s)
      Arai YC P, Morimoto A, Sakurai H, Ohmichi Y, Aono S, Nishihara M, Sato J, Ushida T, Inoue S, Kurisuno M, Kobayashi Y
    • Journal Title

      Journal of Anesthesia

      Volume: 27(1) Pages: 62-65

    • DOI

      10.1007/s00540-012-1467-6

    • Peer Reviewed
  • [Journal Article] Neurolytic celiac plexus block reduces occurrence and duration of ter- minal delirium in patients with pancreatic cancer2013

    • Author(s)
      Arai YC P, Nishihara M, Kobayashi K, Kanazawa T, Hayashi N, Tohyama Y, Nishida K, Arakawa M, Suzuki C, Kinoshita A, Kondo M, Matsubara S, Yokoe N, Hayashi R, Ohta A, Sato J, Ushida T
    • Journal Title

      Journal of Anesthesia

      Volume: 27(1) Pages: 88-92

    • DOI

      10.1007/s00540-012-1486-3

    • Peer Reviewed
  • [Journal Article] Treadmill running and static stretching improve long-lasting hyperalgesia joint limitation and muscle atrophy induced by cast immobilization in rats2013

    • Author(s)
      Morimoto A, Winaga H, Sakurai H, Ohmihi M, Yoshimoto T, Ohmichi Y, Matsui T, Ushida T, Okada T, Sato J
    • Journal Title

      Neuroscience Letters

      Volume: 534 Pages: 295-300

    • DOI

      10.1016/j.neulet.2012.11.009

    • Peer Reviewed
  • [Journal Article] Low barometric pressure aggravates neuropathic pain in guinea pigs2011

    • Author(s)
      Sato J, Itano Y, Funakubo M, Mizoguchi H, Itoh M, Mori R
    • Journal Title

      Neuroscience Letters

      Volume: 503(2) Pages: 152-156

    • DOI

      10.1016/j.neulet.2011.08.030

    • Peer Reviewed
  • [Journal Article] The rate and magnitude of atmospheric pressure change that aggravate pain-related behavior of nerve injured rats2011

    • Author(s)
      Funakubo M, Sato J, Obata K, Mizumura K
    • Journal Title

      International Journal of Biometeorology

      Volume: 55(3) Pages: 319-326

    • DOI

      10.1007/s00484-010-0339-8

    • Peer Reviewed
  • [Journal Article] Comparative effects of acupressure at local and distal acupuncture points on pain conditions and autonomic function in females with chronic neck pain2011

    • Author(s)
      Matsubara T, Arai YC, Shiro Y, Shimo K, Nishihara M, Sato J, Ushida T
    • Journal Title

      Evidence-Based Complementary and Alternative Medicine

      Volume: (Article ID 543291)

    • DOI

      10.1155/2011/543291

    • Peer Reviewed
  • [Journal Article] ストレスと痛み2011

    • Author(s)
      佐藤純
    • Journal Title

      ペインクリニック

      Volume: 32巻, No.12 Pages: 1681−1687

  • [Presentation] 天気痛患者における前庭刺激を用いた知覚閾値測定2014

    • Author(s)
      青野修一, 櫻井博紀, 齋藤愛子, 戸田真弓, 牛田享宏, 佐藤純
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-03-18
  • [Presentation] 気圧変化を感受する機構には内耳前庭が関与する2013

    • Author(s)
      佐藤純
    • Organizer
      第59回日本宇宙航空環境医学大会
    • Place of Presentation
      倉敷
    • Year and Date
      2013-11-24
  • [Presentation] 天気と痛み自律神経の関わり2013

    • Author(s)
      佐藤純
    • Organizer
      第66回日本自律神経学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-10-24
    • Invited
  • [Presentation] ラット神経障害性疼痛モデルと抑うつモデルの寒冷曝露に対するノルアドレナリン反応2013

    • Author(s)
      勝田紘基, 志水泰夫, 深谷由美, 大和恵子, 児玉幸二, 溝口博之, 佐藤純
    • Organizer
      第35回日本疼痛学会
    • Place of Presentation
      大宮
    • Year and Date
      2013-07-13
  • [Presentation] 第22回神経行動薬理若手研究者の集いシンポジウム次世代に向けての行動薬理学とその新展開2013

    • Author(s)
      溝口博之, 福本和哉, 王天, 佐藤純, 山田清文
    • Organizer
      第22回神経行動薬理若手研究者の集いシンポジウム次世代に向けての行動薬理学とその新展開
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-20
  • [Presentation] 姿勢運動パターンによる運動器慢性疼痛患者評価の試み2012

    • Author(s)
      櫻井博紀, 井上雅之, 森本温子, 大道裕介, 井上真輔, 池本竜則, 新井健一, 西原真理, 佐藤純, 牛田享宏
    • Organizer
      第5回日本運動器疼痛学会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-17
  • [Presentation] 気圧センシングメカニズムにおけるTRPチャネルの役割2012

    • Author(s)
      村松寛惟, 佐藤純
    • Organizer
      第51回日本生気象学会大会
    • Place of Presentation
      松本
    • Year and Date
      2012-11-09
  • [Presentation] 痛みと自律神経系2012

    • Author(s)
      佐藤純
    • Organizer
      第65回日本自律神経学会総会シンポジウム4しびれ・痛みと自律神経障害
    • Place of Presentation
      東京
    • Year and Date
      2012-10-25
    • Invited
  • [Presentation] Increase in cold sensitivity of heart rate in a mouse model of anxiety/ depression2012

    • Author(s)
      Sato J, Mizutani Y, Mizoguchi H, Kodama K, Itoh M, Mori R
    • Organizer
      The 35th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Nagoya
    • Year and Date
      2012-09-18
  • [Presentation] Inhibitory effects of tempol, a free radical scavenger, on long-lasting widespread mechanical hyper- algesia in a rat model of cast immobilization2012

    • Author(s)
      Ohmichi Y, Ohmichi M, Sakurai H, Nakano T, Asamoto K, Ushida T, Sato J
    • Organizer
      14th World Congress on Pain
    • Place of Presentation
      Milano
    • Year and Date
      2012-08-27
  • [Presentation] Inhibitory effects of minocycline, an inhibitor of spinal microglial activation, on widespread mech- anical hyperalgesia in a rat model of cast immobilization2012

    • Author(s)
      Ohmichi M, Ohmichi Y, Nakano T, Asamoto K, Ushida T, Ohichi H, Sato J
    • Organizer
      14th World Congress on Pain
    • Place of Presentation
      Milano
    • Year and Date
      2012-08-27
  • [Presentation] Tempolはギプス固定後慢性痛ラットの持続性の広範囲機械痛覚増強と脊髄アストロサイトの活性化を抑制する2012

    • Author(s)
      大道裕介, 大道美香, 櫻井博紀, 浅元憲, 牛田享宏, 佐藤純
    • Organizer
      第34回日本疼痛学会
    • Place of Presentation
      熊本
    • Year and Date
      2012-07-19
  • [Presentation] トレッドミル運動及びストレッチはラット後肢ギプス固定後の機械的痛覚過敏を軽減した2012

    • Author(s)
      森本温子, Winaga Handriadi, 大道裕介, 牛田享宏, 岡田忠, 佐藤純
    • Organizer
      第34回日本疼痛学会
    • Place of Presentation
      熊本
    • Year and Date
      2012-07-19
  • [Presentation] Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetertrazole-treated mice by convert- ing pro-BDNF to mature BDNF in the hippo- campus2012

    • Author(s)
      Mizoguchi H, Sato J, Sawada M, Nabeshima T, Yamada K
    • Organizer
      The 8th FENS Forum of Neuro- science
    • Place of Presentation
      Barcelona
    • Year and Date
      2012-07-14
  • [Presentation] ストレスと痛み2011

    • Author(s)
      佐藤純
    • Organizer
      第8回宮﨑ペインカンファランス
    • Place of Presentation
      宮﨑
    • Year and Date
      2011-11-15
    • Invited
  • [Presentation] 気圧低下環境におけるラット片頭痛行動検出の試み2011

    • Author(s)
      舟久保恵美, 佐藤純, 水村和枝
    • Organizer
      第50回日本生気象学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-11-05
  • [Presentation] 天気と病気2011

    • Author(s)
      佐藤純
    • Organizer
      第4回環境学公開講演会名古屋大学大学院環境学研究科しんきん環境事業イノベーション寄附講座
    • Place of Presentation
      瀬戸
    • Year and Date
      2011-09-27
    • Invited
  • [Presentation] 自律神経と疼痛2011

    • Author(s)
      佐藤純
    • Organizer
      神戸大学がんプロフェッショナル養成プラン講義
    • Place of Presentation
      神戸
    • Year and Date
      2011-09-08
    • Invited
  • [Presentation] 慢性痛のトランスレーショナル・リサーチ-天気痛のメカニズムを動物実験で探る-2011

    • Author(s)
      佐藤純
    • Organizer
      ヒューマンサイエンス振興財団将来動向調査勉強会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-01
    • Invited
  • [Presentation] ストレスと痛み,天候と痛み2011

    • Author(s)
      佐藤純
    • Organizer
      日本ペインクリニック学会第45回大会
    • Place of Presentation
      松山
    • Year and Date
      2011-07-23
    • Invited
  • [Presentation] ラット後肢ギプス固定後の機械的痛覚過敏に対するトレッドミル運動効果についての検討2011

    • Author(s)
      森本温子, 大道裕介, 櫻井博紀, 吉本隆彦, 大道美香, 橋本辰幸, 牛田享宏, 岡田忠, 熊澤孝朗, 佐藤純
    • Place of Presentation
      松山
    • Year and Date
      2011-07-22
  • [Presentation] 運動器慢性痛患者への環境温曝露試験—温度感覚異常を訴える症例の検討—2011

    • Author(s)
      櫻井博紀, 佐藤純, 吉本隆彦, 大道裕介, 森本温子, 大道美香, 西原真理, 新井健一, 牛田享宏
    • Organizer
      第46回日本理学療法学術大会
    • Place of Presentation
      宮﨑
    • Year and Date
      2011-05-28
  • [Presentation] 痛みと天気と自律神経2011

    • Author(s)
      佐藤純
    • Organizer
      第2回兵庫県痛みを考える会
    • Place of Presentation
      神戸
    • Year and Date
      2011-04-28
    • Invited
  • [Book] 天気と病気、未来へつなぐたからもの持続可能な社会を考える2012

    • Author(s)
      佐藤純
    • Total Pages
      267
    • Publisher
      風媒社出版

URL: 

Published: 2015-07-16  

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