2013 Fiscal Year Final Research Report
Global gene expression analysis of mechanical hyperalgesia induced by repeated cold stress in rats
| Project/Area Number |
23590724
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Kinjo Gakuin University |
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Principal Investigator |
KOZAKI Yasuko 金城学院大学, 薬学部, 准教授 (20126882)
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| Co-Investigator(Kenkyū-buntansha) |
KITAMORI Kazuya 金城学院大学, 生泺環境学部, 准教授 (80387597)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 繰り返し低温ストレス / 痛覚過敏 / 遺伝子発現 / 末梢性疼痛機序 |
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| Research Abstract |
Repeated cold stress (RCS) is known to transiently induce autonomic imbalance associated with hypotension and hyperalgesia. This hyperalgesia is thought to be caused by hypofunction of pain inhibitory systems. In this study, we detected changes in pain-related genes expression in the dorsal root ganglion cells (DRGs) by means of two methods, PCR-based cDNA subtraction analysis and DNA microarray analysis in SHRSP5/Dmcr rats. We found significant increase or decrease expressions in eight pain related genes at post-RCS. At least some of these genes in DRG may play key roles to hyperalgesia induced by RCS.
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