一般集団における軽度認知機能障害と動脈硬化との関連に関する疫学研究

2013 Fiscal Year Annual Research Report

• Project/Area Number: 23590790
• Research Institution: Shiga University of Medical Science
• Principal Investigator: 藤吉 朗 滋賀医科大学, 医学部, 准教授 (10567077)
• Co-Investigator(Kenkyū-buntansha): 上島 弘嗣 滋賀医科大学, アジア疫学研究センター, 特任教授 (70144483)
• Keywords: 軽度認知機能低下 / 一般集団 / 腎機能

Research Abstract

本研究は現在進行中の潜在性動脈硬化に関するコホート研究対象者に認知機能検査の一つであるCognitive Assessment Screening Instrument (CASI)を行い、軽度認知機能障害と動脈硬化性変化などとの関連を検討するものである。
平成25年度も引き続き認知機能検査を行い、当初の計画目標であった400名を大きく上回る対象者に検査を施行することができた（平成26年3月31日現在合計751名）。平成25年度はデータ整備（潜在性動脈硬化指標としての冠動脈石灰化スコア、上腕－足踝脈波伝達速度(brachial-ankle pulse wave velocity: baPWV)、ABI（足関節・上腕血圧指数）などの指標を突合）後の予備解析、学会発表、採点者間の一致性検討などを行った。
65歳－81歳の対象者約540名を対象とした解析の結果、認知機能の低下と慢性腎臓病（推定糸球体濾過量および尿タンパクの両者とも）との関連が示唆され、その成果を第49回日本循環器予防学会・日本循環器管理研究協議会総会（平成25年6月15日石川県金沢市金沢市文化ホール）にて発表した（口演）。
また採点者間（3名）に系統的差がないかを検討する目的で、20名の対象者の面接録音を再度他2名の採点者に採点してもらい一致性を検討した。その結果、採点者間での系統的な差（バイアス）がなくPearson相関係数および組内相関係数ともに0.95以上と非常に高い一致性が確認された。この結果を基に、予備解析以降に新たに加わえた対象者データも含めたうえで、再度詳細な解析を行い論文化を進めていく方針である。

Research Products

• [Journal Article] Particle numbers of lipoprotein subclasses and arterial stiffness among middle-aged men from the ERA JUMP study. (2014)
  • Author(s): Vishnu A, Choo J, Masaki KH, Mackey RH, Barinas-Mitchell E, Shin C, Willcox BJ, El-Saed A, Seto TB, Fujiyoshi A, Miura K, Lee S, Sutton-Tyrrell K, Kuller LH, Ueshima H, Sekikawa A.
  • Journal Title: J Hum Hypertens. Volume: 28 Pages: 111-117
  • DOI: 10.1038/jhh.2013.60
  • Peer Reviewed
• [Journal Article] High long-chain n-3 fatty acid intake attenuates the effect of high resting heart rate on cardiovascular mortality risk: A 24-year follow-up of Japanese general population. (2014)
  • Author(s): Hisamatsu T, Miura K, Ohkubo T, Yamamoto T, Fujiyoshi A, Miyagawa N, Kadota A, Takashima N, Okuda N, Yoshita K, Kita Y, Murakami Y, Nakamura Y, Okamura T, Horie M, Okayama A, Ueshima H.
  • Journal Title: J Cardiol. Volume: 未定 Pages: 未定
  • DOI: S0914-5087(14)00023-9 [pii]
  • Peer Reviewed
• [Journal Article] Long-chain n-3 polyunsaturated fatty acids intake and cardiovascular disease mortality risk in japanese: a 24-year follow-up of NIPPON DATA80. (2014)
  • Author(s): Miyagawa N, Miura K, Okuda N, Kadowaki T, Takashima N, Nagasawa SY, Nakamura Y, Matsumura Y, Hozawa A, Fujiyoshi A, Hisamatsu T, Yoshita K, Sekikawa A, Ohkubo T, Abbott RD, Okamura T, Okayama A, Ueshima H.
  • Journal Title: Atherosclerosis Volume: 232 Pages: 384-389
  • DOI: 10.1016/j.atherosclerosis.2013.11.073
  • Peer Reviewed
• [Journal Article] Impact of Metabolic Syndrome on the Risk of Cardiovascular Disease Mortality in the United States and in Japan. (2014)
  • Author(s): Liu L, Miura K, Fujiyoshi A, Kadota A, Miyagawa N, Nakamura Y, Ohkubo T, Okayama A, Okamura T, Ueshima H.
  • Journal Title: Am J Cardiol. Volume: 113 Pages: 84-89
  • DOI: S0002-9149(13)01940-1 [pii]
  • Peer Reviewed
• [Journal Article] A cross-sectional association of obesity with coronary calcium among Japanese, Koreans, Japanese Americans, and U.S. whites. (2013)
  • Author(s): Fujiyoshi A, Sekikawa A, Shin C, Masaki K, David Curb J, Ohkubo T, Miura K, Kadowaki T, Kadowaki S, Kadota A, Edmundowicz D, Shah A, Evans RW, Bertolet M, Choo J, Willcox BJ, Okamura T, Maegawa H, Murata K, Kuller LH, Ueshima H.
  • Journal Title: Eur Heart J Cardiovasc Imaging. Volume: 14 Pages: 921-927
  • DOI: 10.1093/ehjci/jet080
  • Peer Reviewed
• [Journal Article] A Cross-Sectional Association Between Bone Mineral Density and Parathyroid Hormone and Other Biomarkers in Community-Dwelling Young Adults: The CARDIA Study. (2013)
  • Author(s): Fujiyoshi A, Polgreen LE, Hurley DL, Gross MD, Sidney S, Jacobs DR, Jr.
  • Journal Title: J Clin Endocrinol Metab. Volume: 98 Pages: 4038-4046
  • DOI: 10.1210/jc.2013-2198
  • Peer Reviewed
• [Journal Article] Epidemiology of cardiovascular risk factors in asian countries. (2013)
  • Author(s): Nguyen HN, Fujiyoshi A, Abbott RD, Miura K.
  • Journal Title: Circ J. Volume: 77 Pages: 2851-2859
  • DOI: DN/JST.JSTAGE/circj/CJ-13-1292 [pii]
  • Peer Reviewed
• [Journal Article] Association between alanine aminotransferase and intracerebral hemorrhage in East Asian populations. (2013)
  • Author(s): Kim HC, Oh SM, Pan WH, Ueshima H, Gu D, Chuang SY, Fujiyoshi A, Li Y, Zhao L, Suh I.
  • Journal Title: Neuroepidemiology. Volume: 41 Pages: 131-138
  • DOI: 10.1159/000353186
  • Peer Reviewed
• [Journal Article] Carotid Intima-Media Thickness and Plaque in Apparently Healthy Japanese Individuals with an Estimated 10-Year Absolute Risk of CAD Death According to the Japan Atherosclerosis Society (JAS) Guidelines 2012: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). (2013)
  • Author(s): Kadota A, Miura K, Okamura T, Fujiyoshi A, Ohkubo T, Kadowaki T, Takashima N, Hisamatsu T, Nakamura Y, Kasagi F, Maegawa H, Kashiwagi A, Ueshima H.
  • Journal Title: J Atheroscler Thromb. Volume: 20 Pages: 755-766
  • DOI: DN/JST.JSTAGE/jat/17244 [pii]
  • Peer Reviewed
• [Journal Article] Interaction between dietary marine-derived n-3 fatty acids intake and J-point elevation on the risk of cardiac death: a 24-year follow-up of Japanese men. (2013)
  • Author(s): Hisamatsu T, Miura K, Ohkubo T, Yamamoto T, Fujiyoshi A, Miyagawa N, Kadota A, Takashima N, Okuda N, Matsumura Y, Yoshita K, Kita Y, Murakami Y, Nakamura Y, Okamura T, Horie M, Okayama A, Ueshima H.
  • Journal Title: Heart. Volume: 99 Pages: 1024-1029
  • DOI: 10.1136/heartjnl-2012-303496
  • Peer Reviewed
• [Presentation] Relationship Of Plasma Asymmetrical Dimethylarginine To Carotid Intima-media Thickness In General Japanese Population: The ERA-JUMP And The SESSA (2014)
  • Author(s): Shin-ya Nagasawa, Katsuyuki Miura, Akira Fujiyoshi, Aya Kadota, Takayoshi Ohkubo, Takashi Hisamatsu, Sayaka Kadowaki, Naoko Miyagawa, Sayuki Torii, Maryam Zaid, Kamal Masaki, Emma J.M. Barinas-Mitchell, Marrianne H. Bertolet, Rhobert W. Evans, Aiman El-Saed, Lewis H. Kuller, Akira Sekikawa, Hirotsugu Ueshima
  • Organizer: AHA Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2014 Scientific Sessions
  • Place of Presentation: Hilton San Francisco Union Square, SanFrancisco, 米国
  • Year and Date: 20140318-20140321
• [Presentation] Serum Soy Isoflavones Are Inversely Associated With Coronary Artery Calcification In A Population-based Sample Of 299 Men In Japan (2014)
  • Author(s): Akira Sekikawa,Katsuyuki Miura, Abhishek Vishnu, Akira Fujiyoshi, Rhobert W Evans, Takashi Kadowaki, Daniel Edmundowicz,Takashi Hisamatsu, Vasudha Ahuja, Hiroshi Maegawa, Marianne Bertolet, Kiyoshi Murata, Tomonori Okamura, Emma J Barinas-Mitchell, Yasuyuki Nakamura,Lewis H Kuller, Hirotsugu Ueshima
  • Organizer: AHA Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2014 Scientific Sessions
  • Place of Presentation: Hilton San Francisco Union Square, SanFrancisco, 米国
  • Year and Date: 20140318-20140321
• [Presentation] Racial Differences In The Progression Of Carotid Intima-media Thickness In Middle-aged Men-the Era Jump Study (2014)
  • Author(s): Vasudha Ahuja, Emma J Barinas-Mitchell, Todd B Seto, Rhobert Evans, Aya Kadota, Samar R El Khoudary, Akira Fujiyoshi, Abhishek Vishnu, Katsuyuki Miura, Bradley J Willcox, Hirotsugu Ueshima, Kamal Masaki, Lewis H Kuller, Akira Sekikawa
  • Organizer: AHA Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2014 Scientific Sessions
  • Place of Presentation: Hilton San Francisco Union Square, SanFrancisco, 米国
  • Year and Date: 20140318-20140321
• [Presentation] Association of Serum Soy Isoflavones with Metabolic Markers in Japanese Men and Women (2014)
  • Author(s): Rhobert W Evans, Akira Sekikawa,Takashi Kadowaki, Abhishek Vishnu, Sayaka Kadowaki, Aiman El-Saed, Akira Fujiyoshi, Vasudha Ahuja, Tomonori Okamura, Katsuyuki Miura, Lewis H Kuller, Hirotsugu Ueshima
  • Organizer: AHA Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2014 Scientific Sessions
  • Place of Presentation: Hilton San Francisco Union Square, SanFrancisco, 米国
  • Year and Date: 20140318-20140321
• [Presentation] 高齢男性における慢性腎臓病と認知機能との関連：滋賀動脈硬化疫学研究
  • Author(s): 藤吉朗、大久保孝義、三浦克之、椎野顕彦、宮川尚子、高嶋直敬、齋藤祥乃、鳥居さゆ希、門田文、門脇紗也佳、久松隆史、宮澤伊都子、上島弘嗣 for the SESSA Research Group
  • Organizer: 第49回日本循環器予防学会・日本循環器管理研究協議会総会
  • Place of Presentation: 石川県金沢市 金沢市文化ホール
• [Presentation] Lifetime Cigarette Smoking is Associated with Increased Indices of Abdominal Obesity Independent of Body Mass Index: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)
  • Author(s): Akira Fujiyoshi, Katsuyuki Miura, Sayaka Kadowaki, Aya Kadota, Takayoshi Ohkubo, Naoko Miyagawa, Takashi Hisamatsu, Saitoh Yoshino, Sayuki Torii, Itsuko Miyazawa, Kenichi Mitsunami, Hiroshi Maegawa, Kiyoshi Murata, Hirotsugu Ueshima,
  • Organizer: AHA Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2014 Scientific Sessions
  • Place of Presentation: Hilton San Francisco Union Square, SanFrancisco, 米国
• [Presentation] １日のエネルギー摂取量と死亡リスクとの関連：NIPPON DATA80
  • Author(s): 永井雅人、藤吉朗、大久保孝義、三浦克之、奥田奈賀子、早川岳人、由田克士、荒井裕介、中川秀昭、中村幸志、宮川尚子、高嶋直敬、門田文、村上義孝、岡村智教、岡山明、上島弘嗣： NIPPON DATA80 研究グループ
  • Organizer: 第49回日本循環器予防学会・日本循環器管理研究協議会総会
  • Place of Presentation: 石川県金沢市 金沢市文化ホール
• [Presentation] 生涯非飲酒者における危険因子と栄養摂取の特性：INTERLIPID 日本研究
  • Author(s): 宮川尚子、三浦克之、藤吉朗、鳥居さゆ希、奥田奈賀子、由田克士、中川秀昭、斎藤重幸、坂田清美、岡山明、Jeremiah Stamler、上島弘嗣 INTERMAP-INTERLIPID 研究グループ
  • Organizer: 第49回日本循環器予防学会・日本循環器管理研究協議会総会
  • Place of Presentation: 石川県金沢市 金沢市文化ホール
• [Presentation] 日本人男性における心臓周囲脂肪と肥満指標との関連：滋賀動脈硬化研究(SESSA)
  • Author(s): 宮澤伊都子、大久保孝義、三浦克之、藤吉朗、門脇紗也佳、宮川尚子、高嶋直敬、斉藤祥乃、鳥居さゆ希、久松隆史、門田文、前川聡、上島弘嗣 for the SESSA Research Group
  • Organizer: 第49回日本循環器予防学会・日本循環器管理研究協議会総会
  • Place of Presentation: 石川県金沢市 金沢市文化ホール
• [Presentation] Relationship of High-density Lipoprotein Cholesterol and Particle Concentrations with Subclinical Carotid Atherosclerosis in Japanese Men
  • Author(s): Akira Fujiyoshi, Maryam Zaid, Katsuyuki Miura, Tomonori Okamura, Naoyuki Takashima, Sayuki Torii, Yoshino Saito, Takashi Hisamatsu, Naoko Miyagawa,Takayoshi Ohkubo, Aya Kadota, Hiroshi Maegawa,Yasuyuki Nakamura, Kenichi Mitsunami, Hirotsugu Ueshima, For the SESSA Research group
  • Organizer: 第45回日本動脈硬化学会・学術集会
  • Place of Presentation: 東京新宿 京王プラザホテル
• [Presentation] Lipoprotein Particle Profiles by Nuclear Magnetic Resonance, Standard Lipids and Coronary Artery Calcification in a Japanese General Population: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)
  • Author(s): Takashi Hisamatsu, Katsuyuki Miura, Takayoshi Ohkubo, Akira Fujiyoshi, Aya Kadota, Sayaka Kadowaki, Naoko Miyagawa, Sayuki Torii, Yoshino Saitoh, Maryam Zaid, Naoyuki Takashima, Yoshitaka Murakami, Tomonori Okamura, Minoru Horie, Hirotsugu Ueshima
  • Organizer: 第45回日本動脈硬化学会・学術集会
  • Place of Presentation: 東京新宿 京王プラザホテル
• [Presentation] 低炭水化物食と心血管死、総死亡との関連：NIPPONDATA80、29年追跡
  • Author(s): 中村保幸、奥田奈賀子、岡村智教、門田文、宮川尚子、早川岳人、喜多義邦、藤吉朗、永井雅人、高嶋直敬、大久保孝義、三浦克之、岡山明、上島弘嗣
  • Organizer: 第24回日本疫学会学術総会
  • Place of Presentation: 仙台：艮陵会館・日立システムズホール仙台（仙台市青年文化センター）
• [Presentation] 高血圧・喫煙・糖尿病の集積・組み合わせと平均余命の関連：NIPPON DATA80
  • Author(s): 永井雅人、村上義孝、三浦克之、早川岳人、喜多義邦、藤吉朗、高嶋直敬、大久保孝義、岡村智教、岡山明、上島弘嗣 NIPPON DATA80研究グループ
  • Organizer: 第24回日本疫学会学術総会
  • Place of Presentation: 仙台：艮陵会館・日立システムズホール仙台（仙台市青年文化センター）
• [Presentation] Association of Dietary Fatty Acid Intake with Serum High-density Lipoprotein Particle Concentration
  • Author(s): Maryam Zaid, Katsuyuki Miura, Akira Fujiyoshi, Akira Okayama, Hideaki Nakagawa, Kiyomi Sakata, Shigeyuki Saito, Nagako Okuda, Nutrition, Katsushi Yoshita, Sohel Choudhury, Beatriz Rodriguez, Kamal Masaki, Bradley Willcox, Naoko Miyagawa, Jeremiah Stamler, Hirotsugu Ueshima
  • Organizer: AHA Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2014 Scientific Sessions
  • Place of Presentation: Hilton San Francisco Union Square, SanFrancisco, 米国
• [Remarks] 「滋賀医科大学公衆衛生学部門」
  • URL: http://hs-web.shiga-med.ac.jp/