A population-based epidemiological study on the association between mild cognitive impairment and atherosclerosis

2013 Fiscal Year Final Research Report

• Project/Area Number: 23590790
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Shiga University of Medical Science
• Principal Investigator: FUJIYOSHI Akira 滋賀医科大学, 医学部, 准教授 (10567077)
• Co-Investigator(Kenkyū-buntansha): UESHIMA Hirotsugu 滋賀医科大学, アジア疫学研究センター, 特任教授 (70144483)
• Co-Investigator(Renkei-kenkyūsha): MIURA Katsuyuki 滋賀医科大学, 医学部, 教授 (90257452) ; OHKUBO Takayoshi 帝京大学, 医学部, 教授 (60344652) ; SHIINO Akihiko 滋賀医科大学, MR医学総合研究センター, 准教授 (50215935) ; KADOTA Aya 大阪教育大学, 教育学部, 准教授 (60546068) ; TAKASHIMA Naoyuki 滋賀医科大学, 医学部, 特任助教 (80435883) ; MIYAGAWA Naoko 滋賀医科大学, アジア疫学研究センター, 特任助手 (20388169)
• Project Period (FY): 2011 – 2013
• Keywords: 軽度認知機能障害 / 一般集団 / 腎機能

Research Abstract

The aim of the project is to investigate association of cognitive ability with atherosclerosis-related factors. By the end of fiscal year of 2013 (Mar.2014), we were able to conduct examinations on more participants (751) than initially planned (400). ]
Preliminary analysis on 540 participants suggested an association of chronic kidney disease with cognitive decline, which we orally presented in an academic meeting held by the Japan Society of Cardiovascular Disease Prevention (June 15, 2013). We confirmed that there was no evidence of bias according to scorer of the cognitive function test. With further analyses combining more data, we will submit our final result to an academic journal soon.

Research Products

• [Journal Article] Particle numbers of lipoprotein subclasses and arterial stiffness among middle-aged men from the ERAJUMP study (2014)
  • Author(s): Vishnu A, Choo J, Masaki KH, Mackey RH, Barinas-Mitchell E, Shin C, Willcox BJ, El-Saed A, Seto TB, Fujiyoshi A, Miura K, Lee S, Sutton-Tyrrell K, Kuller LH, Ueshima H, Sekikawa A
  • Journal Title: J Hum Hypertens Volume: 28 Pages: 111-117
  • DOI: 10.1038/jhh.2013.60
• [Journal Article] A cross-sectional association of obesity with coronary calcium among Japanese, Koreans, Japanese Americans, and U.S. whites (2013)
  • Author(s): Fujiyoshi A, Sekikawa A, Shin C, Masaki K, David Curb J, Ohkubo T, Miura K, Kadowaki T, Kadowaki S, Kadota A, Edmundowicz D, Shah A, Evans RW, Bertolet M, Choo J, Willcox BJ, Okamura T, Maegawa H, Murata K, Kuller LH, Ueshima H
  • Journal Title: Eur Heart J Cardiovasc Imaging Volume: 14 Pages: 921-7
  • DOI: 10.1093/ehjci/jet080
• [Journal Article] A Cross-Sectional Association Between Bone Mineral Density and Parathyroid Hormone and Other Biomarkers in Community-Dwelling Young Adults : The CARDIA Study (2013)
  • Author(s): Fujiyoshi A, Polgreen LE, Hurley DL, Gross MD, Sidney S, Jacobs DR, Jr
  • Journal Title: J Clin Endocrinol Metab Volume: 98 Pages: 4038-46
  • DOI: 10.1210/jc.2013-2198
• [Journal Article] Epidemiology of cardiovascular risk factors in Asian countries (2013)
  • Author(s): Nguyen HN, Fujiyoshi A, Abbott RD, Miura K
  • Journal Title: Circ J Volume: 77(DN/JST.JSTAGE/circj/CJ-13-1292 [pii]) Pages: 2851-2859
• [Journal Article] Cross-sectional comparison of coronary artery calcium between Caucasian men in the United States and Japanese men in Japan : The Multi-Ethnic Study of Atherosclerosis and the Shiga Epidemiological Study of Subclinical Atherosclerosis
  • Author(s): Akira Fujiyoshi, Katsuyuki Miura, Takayoshi Ohkubo, Takashi Kadowaki, Sayaka Kadowaki, Maryam Zaid, Takashi Hisamatsu, Akira Sekikawa, Matthew J. Budoff, Kiang Liu, Hirotsugu Ueshima
  • Journal Title: Am J Epidemiol Volume: (in press)
  • DOI: 10.1093/aje/kwu169
• [Presentation] Lifetime Cigarette Smoking is Associated with Increased Indices of Abdominal Obesity Independent of Body Mass Index : The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) (2014)
  • Author(s): Akira Fujiyoshi, Katsuyuki Miura, Sayaka Kadowaki, Aya Kadota, Takayoshi Ohkubo, Naoko Miyagawa, Takashi Hisamatsu, Saitoh Yoshino, Sayuki Torii, Itsuko Miyazawa, Kenichi Mitsunami, Hiroshi Maegawa, Kiyoshi Murata, Hirotsugu Ueshima
  • Organizer: AHA Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2014 Scientific Sessions
  • Place of Presentation: San Francisco,米国
  • Year and Date: 2014-03-19
• [Presentation] Relationship of High-density Lipoprotein Cholesterol and Particle Concentrations with Subclinical Carotid Atherosclerosis in Japanese Men (2013)
  • Author(s): Akira Fujiyoshi, Maryam Zaid, Katsuyuki Miura, Tomonori Okamura, NaoyukiTakashima, Sayuki Torii, Yoshino Saito, Takashi Hisamatsu, Naoko Miyagawa, Takayoshi Ohkubo, Aya Kadota, Hiroshi Maegawa, Yasuyuki Nakamura, Kenichi Mitsunami, Hirotsugu Ueshima, For the SESSA Research group
  • Organizer: 第45回日本動脈硬化学会・学術集会
  • Place of Presentation: 東京新宿京王プラザホテル
  • Year and Date: 2013-07-18
• [Presentation] 高齢男性における慢性腎臓病と認知機能との関連:滋賀動脈硬化疫学研究 (2013)
  • Author(s): 藤吉朗, 大久保孝義, 三浦克之, 椎野顕彦, 宮川尚子, 高嶋直敬, 齋藤祥乃, 鳥居さゆ希, 門田文, 門脇紗也佳, 久松隆史, 宮澤伊都子, 上島弘嗣, for the SESSA Research Group
  • Organizer: 第49回日本循環器予防学会・日本循環器管理研究協議会総会
  • Place of Presentation: 石川県金沢市金沢市文化ホール
  • Year and Date: 2013-06-15
• [Presentation] 1日のエネルギー摂取量と死亡リスクとの関連:NIPPON DATA80 (2013)
  • Author(s): 永井雅人, 藤吉朗, 大久保孝義, 三浦克之, 奥田奈賀子, 早川岳人, 由田克士, 荒井裕介, 中川秀昭, 中村幸志, 宮川尚子, 高嶋直敬, 門田文, 村上義孝, 岡村智教, 岡山明, 上島弘嗣, NIPPON DATA80研究グループ
  • Organizer: 第49回日本循環器予防学会・日本循環器管理研究協議会総会
  • Place of Presentation: 石川県金沢市金沢市文化ホール
  • Year and Date: 2013-06-14
• [Presentation] 生涯非飲酒者における危険因子と栄養摂取の特性:INTERLIPID日本研究 (2013)
  • Author(s): 宮川尚子, 三浦克之, 藤吉朗, 鳥居さゆ希, 奥田奈賀子, 由田克士, 中川秀昭, 斎藤重幸, 坂田清美, 岡山明, Jeremiah Stamler, 上島弘嗣, INTERMAP-INTERLIPID研究グループ
  • Organizer: 第49回日本循環器予防学会・日本循環器管理研究協議会総会
  • Place of Presentation: 石川県金沢市金沢市文化ホール
  • Year and Date: 2013-06-14
• [Remarks]
  • URL: http://hs-web.shiga-med.ac.jp/