Epidemiologic study on chronic atrophic gastritis with obesity and following metabolic syndrome

2013 Fiscal Year Final Research Report

• Project/Area Number: 23590806
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Nagoya City University
• Principal Investigator: SUZUKI Sadao 名古屋市立大学, 医学(系)研究科(研究院), 教授 (20226509)
• Project Period (FY): 2011 – 2013
• Keywords: 慢性萎縮性胃炎 / ペプシノーゲンテスト / メタボリックシンドローム / ピロリ菌除菌

Research Abstract

Since chronic atrophic gastritis (CAG) is one of the risk factors of gastric cancer, eradication of Helicobacter pylori (HP) is widely performed. On the other hand, malfunction of stomach from CAG could cause of inadequate absorption and sequentially could prevent obesity and metabolic syndrome (MetS). In this study, subjects with/without CAG were compared in obesity index and factors included in MetS diagnosis in order to evaluate the CAG in public health aspect.
Obesity index were not different in their CAG status, and no obvious results of strong association were observed between CAG and MetS related factors. Thus, CAG are not associated to obesity and following MetS, and eradication of HP could be recommended.

Research Products

• [Journal Article] The preventive effects of low-dose enteric-coated aspirin tablets on the development of colorectal tumours in Asian patients : a randomised trial (2014)
  • Author(s): Ishikawa H, Mutoh M, Suzuki S, Tokudome S, Saida Y, Abe T, Okamura S, Tajika M, Joh T, Tanaka S, Kudo SE, Matsuda T, Iimuro M, Yukawa T, Takayama T, Sato Y, Lee K, Kitamura S, Mizuno M, Sano Y, Gondo N, Sugimoto K, Kusunoki M, Goto C, Matsuura N, Sakai T, Wakabayashi K
  • Journal Title: Gut
  • DOI: 10.1136/gutjnl-2013-305827
• [Journal Article] Obesity/ weight gain and breast cancer risk : findings from the Japan collaborative cohort study for the evaluation of cancer risk (2013)
  • Author(s): Suzuki S, Kojima M, Tokudome S, Mori M, Sakauchi F, Wakai K, Fujino Y, Lin Y, Kikuchi S, Tamakoshi K, Tamakoshi A
  • Journal Title: J Epidemiol Volume: 23 Pages: 139-45
  • DOI: 10.2188/jea.JE20120102
• [Journal Article] Genome-wide association study of the genetic factors related to confectionery intake : Potential roles of the ADIPOQ gene (2013)
  • Author(s): Wakai K, Matsuo K, Matsuda F, Yamada R, Takahashi M, Kawaguchi T, Yatabe Y, Ito H, Hosono S, Tajima K, Naito M, Morita E, Yin G, Sakamoto T, Takashima N, Suzuki S, Nakahata N, Mikami H, Ohnaka K, Watanabe Y, Arisawa K, Kubo M, Hamajima N, Tanaka H; the J-MICC Study Group
  • Journal Title: Obesity (Silver Spring)
  • DOI: 10.1002/oby.200316
• [Journal Article] Detailed analysis of Japanese population substructure with a focus on the southwest islands of Japan (2012)
  • Author(s): Nishiyama T, Kishino H, Suzuki S, Ando R, Niimura H, Uemura H, Horita M, Ohnaka K, Kuriyama N, Mikami H, Takashima N, Mastuo K, Guang Y, Wakai K, Hamajima N, Tanaka H; J-MICC Study Group
  • Journal Title: PLoS One Volume: 7(4) Pages: e35000
  • DOI: 10.1371/journal.pone.0035000
• [Journal Article] glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study (2012)
  • Author(s): Hishida A, Morita E, Naito M, Okada R, Wakai K, Matsuo K, Nakamura K, Takashima N, Suzuki S, Takezaki T, Mikami H, Ohnaka K, Watanabe Y, Uemura H, Kubo M, Tanaka H, Hamajima N
  • Journal Title: Endocr J Volume: 59 Pages: 589-99
  • URL: https://www.jstage.jst.go.jp/article/endocrj/59/7/59_EJ11-0310/_pdf.AssociationsofapolipoproteinA5(APOA5)
• [Journal Article] Matrix metalloproteinase-9 gene polymorphisms and chronic kidney disease (2012)
  • Author(s): Okada R, Kawai S, Naito M, Hishida A, Hamajima N, Shinchi K, Chowdhury Turin T, Suzuki S, Mantjoro EM, Toyomura K, Arisawa K, Kuriyama N, Hosono S, Mikami H, Kubo M, Tanaka H, Wakai K; Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group
  • Journal Title: Am J Nephrol Volume: 36 Pages: 444-50
  • DOI: 10.1159/000343742
• [Journal Article] Association between the catechol-O- methyltransferase (rs4680: Val158Met) polymorphism and serum alanine aminotransferase activity (2012)
  • Author(s): Hiyoshi M, Uemura H, Arisawa K, Nakamoto M, Hishida A, Okada R, Matsuo K, Kita Y, Niimura H, Kuriyama N, Nanri H, Ohnaka K, Suzuki S, Mikami H, Kubo M, Tanaka H, Hamajima N; J-MICC Study Group
  • Journal Title: Gene Volume: 496 Pages: 97-102
  • DOI: 10.1016/j.gene.2012
• [Journal Article] Gene variants in PPARD and PPARGC1A are associated with timing of natural menopause in the general Japanese population (2012)
  • Author(s): Uemura H, Hiyoshi M, Arisawa K, Yamaguchi M, Naito M, Kawai S, Hamajima N, Matsuo K, Taguchi N, Takashima N, Suzuki S, Hirasada K, Mikami H, Ohnaka K, Yoshikawa A, Kubo M, Tanaka H; Japan Multi- institutional Collaborative Cohort
  • Journal Title: Maturitas Volume: 71 Pages: 369-75
  • DOI: 10.1016/j.maturitas.2011.12.021
• [Journal Article] Pro-/anti-infla mmatory cytokine gene polymorphisms and chronic kidney disease : a cross-sectional study (2012)
  • Author(s): Okada R, Wakai K, Naito M, Morita E, Kawai S, Hamajima N, Hara M, Takashima N, Suzuki S, Takezaki T, Ohnaka K, Arisawa K, Hirohata H, Matsuo K, Mikami H, Kubo M, Tanaka H; Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group
  • Journal Title: BMC Nephrol Volume: 13 Pages: 2
  • DOI: 10.1186/1471-2369-13-2
• [Presentation] 人間ドックにおける萎縮性胃炎の分布と関連因子 (2014)
  • Author(s): 鈴木貞夫, 小嶋雅代, 西山毅, 荒井健介, 辻村尚子, 岡京子, 藤田ひとみ, 神谷真有美, 近藤文, 鈴木美奈, 今枝奈保美, 石川奈美, 柴田清, 後藤千穂, 安藤亮介, 細野晃弘, 深津満,山田珠樹,徳留信寛
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪府大阪市(大阪大学コンベンションセンター)
  • Year and Date: 20140124-26
• [Presentation] 地域住民のペプシノーゲン検査による萎縮性胃炎の評価と関連因子について (2014)
  • Author(s): 鈴木貞夫, 小嶋雅代, 細野晃弘, 荒井健介, 辻村尚子, 岡京子, 藤田ひとみ, 岡本尚子, 神谷真有美, 近藤文, 鈴木美奈
  • Organizer: 第24回日本疫学会学術総会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 20140124-25
• [Presentation] 慢性萎縮性胃炎の疫学-肥満との関連を中心に (2013)
  • Author(s): 鈴木貞夫, 小嶋雅代, 細野晃弘, 柴田清, 荒井健介, 辻村尚子, 岡京子, 藤田ひとみ, 岡本尚子, 神谷真有美, 近藤文, 鈴木美奈
  • Organizer: 第72回日本公衆衛生学会総会
  • Place of Presentation: 三重県津市(三重県総合文化センター)
  • Year and Date: 20131023-25