2014 Fiscal Year Final Research Report
Developement of new screening system for detecting onlyclinical significant prostate cancer
| Project/Area Number |
23590812
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKASHIMA Jun 東京医科大学, 医学部, 教授 (10167546)
MIZUNO Ryuichi 慶應義塾大学, 医学部, 講師 (60383824)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | 前立腺癌 / スクリーニング / ノモグラム / バイオマーカー |
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| Outline of Final Research Achievements |
In this study, we investigated that PCA3 score and other parameter can predict ‘significant carcinoma’ in biopsy specimen. According to Receiver operating characteristics (ROC) analysis, PCA3 score had the greater AUC for predicting all prostate all cancer as well as positive core more than 2. However, ROC predicting significant cancer showed PCA3 score showed less AUC than PSA free/total ratio. A stepwise multivariate logistic regression analysis revealed that both PSA F/T and PCA3 score were the independent significant predictors of significant cancers. Using these two factors, a nomogram was developed to predict significant cancers in biopsy. In ROC analysis, the value of nomogram showed a greater AUC than any other single factors.
Because PSA F/T ratio and PCA3 sore were measured easily from the patient’s sample, this nomogram seems to be useful for men with moderately elevated PSA to introduce more precise clinical management plans.
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| Free Research Field |
泌尿器科学
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