Epidemiological study on the association of chronic kidney disease with oxidative stress and abnormal secretion of adipokines

2013 Fiscal Year Final Research Report

• Project/Area Number: 23590820
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Fujita Health University
• Principal Investigator: KOJI Suzuki 藤田保健衛生大学, 医療科学部, 准教授 (60288470)
• Co-Investigator(Kenkyū-buntansha): ICHINO Naohiro 藤田保健衛生大学, 医療科学部, 准教授 (50278280)
• Project Period (FY): 2011 – 2013
• Keywords: 慢性腎臓病 / 酸化ストレス / アディポカイン / miRNA / カロテノイド / 疫学研究

Research Abstract

This study investigated the associations of kidney function with serum levels of carotenoids, adipokines, and miRNAs which are involved in vascular endothelial function, among Japanese adults who attended a health examination. Increased levels of serum provitamin A, especially serum beta-carotene, were independently associated with lower risk of albuminuria among women. Serum resistin levels were positively associated with serum cystatin C levels in both sexes. Longitudinal study showed that increases in body mass and serum resistin levels were associated with decrease in estimated glomerular filtration rate (eGFR). Moreover serum miR-21 and 122 were increased in albuminuria group compared with normal group, and serum miR-126 levels were independently and positively associated with eGFR. Kidney function decline was implicated with oxidative stress, abnormal resistin secretion, and changes in serum miRNAs which affect vascular endothelial dysfunction.

Research Products

• [Journal Article] Association of serum carotenoid levels with urinary albumin excretion in a general Japanese population : the yakumo study (2013)
  • Author(s): Suzuki K, Honjo H, Ichino N, Osakabe K, Sugimoto K, Yamada H, Kusuhara Y, Watarai R, Hamajima T, Hamajima N, Inoue T
  • Journal Title: J Epidemiol Volume: 23(6) Pages: 451-6
  • DOI: 10.2188/jea.JE20130058
  • Peer Reviewed
• [Presentation] 住民健診受診者における肥満指標および血清レジスチン値の変化と推算糸球体濾過量の変化との関連. (2014)
  • Author(s): 鈴木康司, 度會理佳, 濱島剛, 山田宏哉, 市野直浩, 刑部恵介, 杉本恵子, 大橋鉱二, 浜島信之, 井上孝
  • Organizer: 第24回日本疫学会学術総会
  • Place of Presentation: 宮城県
  • Year and Date: 2014-01-25
• [Presentation] Serum microRNA-126 levels are associated with kidney function in a Japanese population (2013)
  • Author(s): Suzuki K,Yamada H, Ichino N, Osakab e K, Sugimoto K, Ando Y, Sawada A, Wata rai R, Hamajima T, Kusuhara Y, Hamajima N, Inoue T
  • Organizer: 13th Asia-Paci fic Federation for Clinical Biochemistr y and Laboratory Medicine Congress
  • Place of Presentation: インドネシア,バリ
  • Year and Date: 20131027-30
• [Presentation] Stiffness parameterβassessed by an ultrasonic phase-lock ed echo-tracking system is associated w ith kidney function in a Japanese popul ation (2013)
  • Author(s): I chino N, Suzuki K, Osakabe K, Sugi moto K, Yamada H, Watarai R, Hamajima N, Inoue T, Hata T
  • Organizer: 13th Asia-Pacific Federation fo r Clinical Biochemistry and Laboratory Medicine Congress
  • Place of Presentation: インドネシア,バリ
  • Year and Date: 20131027-30
• [Presentation] 血清シスタチンC値と血清レジスチンおよびカロテノイド値との関連 (2013)
  • Author(s): 鈴木康司, 井上孝, 山田宏哉, 浜島信之
  • Organizer: 第72回日本公衆衛生学会
  • Place of Presentation: 三重県
  • Year and Date: 2013-10-24
• [Presentation] 住民健診受診者におけるアルブミン尿と血清microRNA (miR-21、miR-122)との関連 (2013)
  • Author(s): 鈴木康司, 井上孝, 市野直浩, 刑部恵介, 杉本恵子, 楠原康弘, 落合潤一, 山田宏哉, 伊藤宜則, 浜島信之
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪府
  • Year and Date: 2013-01-25
• [Presentation] 住民健診受診者における微量アルブミン尿と血清カロテノイド値との関連 (2012)
  • Author(s): 鈴木康司, 井上孝, 山田宏哉, 浜島信之
  • Organizer: 第71回日本公衆衛生学会総会
  • Place of Presentation: 山口県
  • Year and Date: 2012-10-25
• [Presentation] 住民検診受診者における推算糸球体濾過量(eGFR)と血清カロテノイド値との関連 (2012)
  • Author(s): 鈴木康司, 井上孝, 市野直浩, 刑部恵介, 杉本恵子, 楠原康弘, 落合潤一, 山田宏哉, 伊藤宜則, 浜島信之
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都府
  • Year and Date: 2012-03-25
• [Presentation] 住民健診受診者におけるメタボリックシンドロームと腎機能低下との関連 (2012)
  • Author(s): 鈴木康司, 井上孝, 市野直浩, 刑部恵介, 杉本恵子, 楠原康弘, 落合潤一, 山田宏哉, 伊藤宜則, 浜島信之
  • Organizer: 第22回日本疫学会学術総会
  • Place of Presentation: 東京都
  • Year and Date: 2012-01-27