Risk evaluation based on the clinical characteristics of Hematological malignancies in atomic bomb survivors

2014 Fiscal Year Final Research Report

• Project/Area Number: 23590829
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Jikei University School of Medicine (2013-2014); Teikyo University (2011-2012)
• Principal Investigator: IWANAGA Masako 東京慈恵会医科大学, 医学部, 講師 (00372772)
• Co-Investigator(Kenkyū-buntansha): MIYAZAKI Yasushi 長崎大学, 原爆後障害医療研究所, 教授 (40304943)
• Research Collaborator: 松尾 正稔 長崎大学, 血液内科, 医員 ; 波多 智子 長崎大学, 血液内科, 准教授 ; 対馬 秀樹 長崎大学, 血液内科, 助教 ; 近藤 久義 長崎大学, 原爆後障害医療研究所, 助教 ; 早田 みどり 長崎県腫瘍登録室, 室長 ; 朝長 万左男 長崎原爆病院, 院長
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: がん疫学 / 臨床疫学 / リスク解析 / 原爆被爆者 / 造血器腫瘍

Outline of Final Research Achievements

To clarify the detailed characteristics of hematological malignancies that occurred in Nagasaki atomic bomb survivors, we conducted clinico-epidemiological studies. We found that (1) myelodysplastic syndromes who were exposed proximally to atomic bomb had a high frequency of the poor chromosome score of the international prognostic scoring system of myelodysplastic syndromes, but exposure distance was not a significant risk-factor for the leukemic transformation and death; (2) monosomy 7 was the most frequent chromosomal abnormality in myelodysplastic syndromes who were exposed proximally, which was similar to chromosomal abnormality in therapy-related leukemia/myelodysplastic syndromes; and (3) exposure distance was not a significant risk-factor for the development of adult T-cell leukemia in atomic bomb survivors, even after adjusting for age and smoking.

Free Research Field

がん疫学