Immunohistological epidemiologic study of breast cancer among atomic-bomb survivors

2014 Fiscal Year Final Research Report

• Project/Area Number: 23590839
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Radiation Effects Research Foundation
• Principal Investigator: OZASA Kotaro 公益財団法人放射線影響研究所, 広島疫学部, 部長 (20204191)
• Research Collaborator: YONEHARA Shuji 厚生連尾道総合病院, 病理研究検査科, 部長 ; NISHISAKA Takashi 広島県立広島病院, 臨床研究検査科, 部長 ; NAKASHIMA Masahiro 長崎大学原爆後障害医療研究所, 腫瘍・診断病理学分野, 教授 ; SADAKANE Atsuko 公益財団法人放射線影響研究所, 広島疫学部病理学研究室, 室長代理 ; SODA Midori 公益財団法人放射線影響研究所, 長崎疫学部, 嘱託研究員 ; FURUKAWA Kyoji 公益財団法人放射線影響研究所, 統計部, 副主任研究員 ; MABUCHI Kiyohiko 米国国立がん研究所, がん疫学・遺伝学部・放射線疫学部門, チェルノブイリ研究班長兼主任研究員
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 放射線 / 疫学 / 原子爆弾 / 乳がん / 内因的サブタイプ / 病理学 / 追跡調査

Outline of Final Research Achievements

Breast cancer cases developed in the cohort of atomic-bomb survivors’ Life Span Study in Hiroshima and Nagasaki were histologically diagnosed and their intrinsic subtypes were classified using immunohistochemical staining methods by pathologist panel. Among 1615 cases of breast cancer that were histologically confirmed, 81% were classified as invasive ductal carcinoma, 6% as in-situ carcinoma. Among 1377 cases that were available for staining for the subtype, 32% were classified as Luminal A, 40% as Luminal B, 8% as HER2-rich, and 9% as triple-negative. After judgement is confirmed, association of these results and radiation exposure, and also association with year of diagnosis from the viewpoint of increase of breast cancer in Japan will be investigated.

Free Research Field

放射線疫学