2013 Fiscal Year Final Research Report
Effects of compounds isolated from traditional drugs on UV-induced photochemotherapy and carcinogenesis and their mechanisms
| Project/Area Number |
23590883
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Ehime University |
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Principal Investigator |
KIMURA Yoshiyuki 愛媛大学, 医学(系)研究科(研究院), 講師 (20294796)
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| Co-Investigator(Renkei-kenkyūsha) |
SUMIYOSHI Maho 愛媛大学, 大学院医学系研究科, 助教 (60444767)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 癌 / 植物成分 / 薬理学 / 生理活性 / 紫外線 |
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| Research Abstract |
Tetrahydroxy-dimethoxyflavone and Pentahydroxyflavanone isolated from Scutellariae Radix inhibited the acute UVB-induced skin inflammation through the inhibition of MMP-9 expression and VEGF production. We found that wogonin isolated from Scutellariae Radix had anti-tumor and anti-metastatic actions through anti-lymphangiogenesis. We found that the anti-proliferative and anti-tumor actions of UVA plus furocoumarins isolated from Umbelliferae medicinal plants were due to G2/M arrest of the cell cycle by an increase in phospho-Chk1 and decrease in phospho-cdc2 of melanoma cells.
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