2013 Fiscal Year Final Research Report
Mice model of cardiac sarcoidosis to understand the pathogenesis and develop clinical diagnostic and therapeutic strategies.
| Project/Area Number |
23590907
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
MOROI Masao 独立行政法人国立国際医療研究センター, その他部局等, 医員 (30256721)
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| Co-Investigator(Kenkyū-buntansha) |
廣江 道昭 独立行政法人国立国際医療研究センター (80101872)
窪田 哲也 独立行政法人国立健康・栄養研究所 (60385698)
今中 恭子 三重大学, 大学院医学研究科 (00242967)
滝 淳一 金沢大学, 核医学研究科 (10251927)
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| Project Period (FY) |
2011 – 2013
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| Keywords | サルコイドーシス / 心筋症 / 心筋炎 / マクロファージ |
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| Research Abstract |
Cardiac sarcoidosis is a chronic disease of unknown etiology characterized by the formation of non-necrotizing epitheloid granulomas. The lack of an adequate animal model reflecting the pathogenesis of the human disease is one of the major impediments in studying sarcoidosis. The purpose of this study was to generate a mouse model of cardiac sarcoidosis to understand its pathogenesis and develop clinical diagnostic and therapeutic strategies.
Apo E-/- mice after 16 weeks on a cholate-containing high-fat diet exhibited macrophage accumulation and interstitial fibrosis in the myocardium where no lymphocytes were observed. Thus, the model presented myocarditis strongly associated with macrophages. Inflammation mainly associated with macrophages could be detected by F-18 FDG PET, but normal myocardial cells also utilize FDG. A clinical study showed FDG PET with a fast of 18 h< can detect active lesions of cardiac sarcoidosis by suppressing normal uptake of myocardium.
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[Journal Article] Long fasting is effective in inhibiting physiological myocardial 18F-FDG uptake and for evaluating active lesions of cardiac sarcoidosis2014
Author(s)
Morooka M, Moroi M, Uno K, Ito K, Wu J, Nakagawa T, Kubota K, Minamimoto R, Miyata Y, Okasaki M, Okazaki O, Yamada Y, Yamaguchi T, Hiroe M
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Journal Title
EJNMMI Res
Volume: 2;4(1)(Epub ahead of print)
Pages: 1
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[Presentation] Significance of cardiac imaging with F-18-DG-PET and Iodine-123 BMIPP SPECT in patients with known or suspected cardiac sarcoidosis2012
Author(s)
Nakagawa, T, Hiroe M, Morooka M, Minamimoto R, Ito K, Kubota K, Yamada Y, Yamaguchi T, Nagata M, Wakiya M, Kamimura M, Ikeda N, Tamori Y , Yamamoto M, Itoh S, Okazaki O, Hara H, Moroi M
Organizer
The 76th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Fukuoka
Year and Date
2012-03-17
