2013 Fiscal Year Final Research Report

Analysis of microRNA expression in the gastric mucosa after successful eradication of Helicobacter pylori

Research Project

Project/Area Number	23590911
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Gastroenterology
Research Institution	The University of Tokyo
Principal Investigator	OHNO Hideki 東京大学, 医科学研究所, 助教 (30396866)
Project Period (FY)	2011 – 2013
Keywords	ヘリコバクター・ピロリ / 除菌 / 胃癌 / マイクロRNA
Research Abstract	The onset of gastric cancer after successful eradication of Helicobacter pylori was reported in recent several studies. We have investigated the dysregulation of micro-RNAs in gastric mucosa of the patients after successful eradication of H. pylori by miRNA microarray. The expression of some miRNAs such as miR-155 were higher in the gastric mucosa of patients after successful eradication than in those not infected with H. pylori. Some of these miRNAs are known to have effects on cell proliferation and carcinogenesis. This result suggests the possibility that the dysregulation of miRNAs in gastric mucosa is involved in the onset of gastric cancer after successful eradication of H. pylori.