2013 Fiscal Year Final Research Report
Are fecal mRNA assay useful for ulcerative colitis ?
| Project/Area Number |
23590935
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURIYAMA Shigeru 浜松医科大学, 医学部, 助教 (90596446)
SUGIMOTO Ken 浜松医科大学, 医学部, 准教授 (20529507)
IWAIZUMI Moriya 浜松医科大学, 医学部, 助教 (60444361)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 潰瘍性大腸炎 / 糞便 / 糞便RNA発現 |
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| Research Abstract |
Fecal CD45 or proinflammatory cytokines mRNA were evaluated as a noninvasive biomarker of disease activity or mucosal inflammation for ulcerative colitis (UC). Total 86 colonoscopies were performed in 73 UC patients. Samples from feces and blood were analyzed for fecal mRNA assay and laboratory findings (CRP, ESR, Hb, Plt, Alb), and the results were compared with colonoscopic findings. Mucosal status was assessed using the Mayo endoscopic score (0-3). There was significant differences in all non-invasive markers and CAI among the Mayo endoscopic score (p < 0.01). Endoscopic disease activity correlated closest with CAI, followed by fecal mRNA assay, Alb, CRP, ESR, Hb, and Plt. In addition, nineteen of 42 patients with Mayo 2 or 3 had CAI less than 5, however, more than half of 19 patients had positive result of fecal mRNA assay when proper cutoff was set. These results suggested that fecal mRNA assay is useful as a noninvasive biomarker of mucosal inflammation for UC.
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[Journal Article] Induction of murine TNBS-induced colitis is strictly controlled by a modified method using continuous inhalation anesthesia with sevoflurane2014
Author(s)
Tomohiro Terai, Satoshi Osawa, Shinya Tani, Shinzi Oishi, Yoshifumi Arai, Takanori Yamada, Mitsushige Sugimoto, Takahisa Furuta, Shigeru Kanaoka, Hiroaki Miyajima, Ken Sugimoto
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Journal Title
Dig Dis Sci
Volume: (Epub ahead of print)
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[Presentation] Fecal Hemoglobin as a Marker for Mucosal inflammation of Ulcerative Colitis : Usefulness of Combination with Rachmilewitz's Clinical Activity Index2014
Author(s)
Shigeru Kanaoka, Shigeru Kuriyama, Moriya Iwaizumi, Takanori Yamada, Mitsushige Sugimoto, Satoshi Osawa, Ken Sugimoto, Yoshisuke Hosoda, Yoshihiko Sato, Masami Yamada, Shigeto Yoshii, Kazuhiko Kawakami, Katsuhiko Nakai, Hiroaki Miyajima
Organizer
2014DDW
Place of Presentation
Chicago
Year and Date
2014-05-03
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