2013 Fiscal Year Final Research Report
Analyses about the role of DDX20 in hepatocarcinogenesis
| Project/Area Number |
23590960
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
GOTO Tadashi 東京大学, 医学部附属病院, 臨床登録医 (40444088)
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| Co-Investigator(Kenkyū-buntansha) |
OTSUKA Motoyuki 東京大学, 医学部附属病院消化器内科, 助教 (90518945)
YOSHIDA Haruhiko 東京大学, 医学部附属病院, 臨床登録医 (60240305)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 肝臓学 / DDX20 / microRNA |
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| Research Abstract |
DDX20 was previously identified as one of the causes of hepatocarcinogenesis. In this project, we identified that DDX20 is a component of RISC, which mediates microRNA maturation. By DDX20 decrease, microRNA140-5p amount was specifically decreased, which enhanced DNMT1 leading to the decrease of metallothionein expression, which is closely related to NFkB activities, a major cause of hepatocarcinogenesis. These phenomena were confirmed in miR140 knockout mice and chemically-induced hepatocarcinogenesis. Therefore, it willbe promising that based on these results, novel preventive methods against hepatocarcinogenesis are developed by further analyses.
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[Journal Article] MiRNA-140 acts as a liver tumor suppressor by controlling NF-kB activity via directly targeting Dnmt1 expression2013
Author(s)
Takata A, Otsuka M, Yoshikawa T, Kishikawa T, Hikiba Y, Obi S, Goto T, Kang Y, Maeda S, Yoshida H, Omata M, Asahara H, Koike K
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Journal Title
Hepatology
Volume: 57(1)
Pages: 162-70
DOI
Peer Reviewed
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