2013 Fiscal Year Final Research Report
Construction of the intraoperative care system with using patient's salivary amylase during endoscopic submucosal dissection under sedation
| Project/Area Number |
23591018
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Chiba University |
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Principal Investigator |
UESATO MASAYA 千葉大学, 医学(系)研究科(研究院), 特任講師 (70436377)
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| Co-Investigator(Kenkyū-buntansha) |
NABEYA Yoshihiro 千葉県がんセンター(研究所), 医療局, 主任医長 (40322028)
HAYASHI Hideki 千葉大学, フロンティアメディカル工学研 究開発センター, 教授 (20312960)
MATSUBARA Hisahiro 千葉大学, 大学院医学研究院, 教授 (20282486)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 唾液アミラーゼ / 術中モニター / 疼痛 / 内視鏡治療 / ＥＳＤ / 臨床 / ストレス |
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| Research Abstract |
The analgesia in patients during endoscopic submucosal dissection (ESD) under deep sedation (DS) has not yet been developed. There was no way of measuring the degree of the pain in those patients. This study revealed that the salivary amylase activity (sAMY) shown as sympathetic excitement sometimes was elevated during ESD without any change in circulatory dynamics or consciousness. We suggest that sAMY is elevated when patients feel pain during ESD under DS. By detecting twice the actual sAMY based on the preoperative level, the release of gastric wall tension or the administration of analgesic agents should be considered.
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