2013 Fiscal Year Final Research Report
Role of ROCK activity in cardiovascular diseases: a translational research
| Project/Area Number |
23591043
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Hiroshima University |
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Principal Investigator |
NOMA KENSUKE 広島大学, 原爆放射線医科学研究所, 助教 (00379893)
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| Co-Investigator(Kenkyū-buntansha) |
HIGASHI Yukihito 広島大学, 原爆放射線医科学研究所, 教授 (40346490)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ROCK / 血管内皮機能 / 心血管障害 / 脳梗塞 / 血管機能 / eNOS |
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| Research Abstract |
From endothelial cellular and murine experiments, we have revealed that ROCK2, one of ROCK isoforms, could destabilize eNOS mRNA via ROCK2-mediated phosphorylation of eEF1A and binding of ROCK2 with 3'-UTR of eNOS mRNA. In addition, we have further found that ROCK2 could regulate cardiac hypertrophy via modulation of FHL2.
From clinical studies, we have revealed that leukocyte ROCK activity could reflect vascular function and could be quite a useful biomarker to predict cardiovascular events.
Therefore, we concluded from such a translational study that ROCK2 could be a promising target in patients with cardiovascular diseases and leukocyte ROCK activity could be a useful biomarker to evaluate vascular function.
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[Journal Article] Rho-associated kinase is a predictor of a predictor of cardiovascular outcomes2013
Author(s)
Kajikawa M, Noma K, Maruhashi T, Mikami S, Iwamoto Y, Iwamoto A, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Nakashima A, Goto C, Liao JK, Higashi Y.
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Journal Title
Hypertension
Volume: 64
Pages: 856-864
DOI
Peer Reviewed
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[Journal Article] Mineralocorticoid Receptor Blocker Eplerenone Improves Endothelial Function and Inhibits Rho-associated Kinase Activity in Patients With Hypertension2012
Author(s)
Fujimura N, Noma K, Hata T, Soga J, Hidaka T, Idei N, Fujii Y, Mikami S, Maruhashi T, Iwamoto Y, Kihara Y, Chayama K, Kato H, Liao JK, Higashi Y.
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Journal Title
Clin Pharmacol Ther
Volume: 91
Pages: 289-297
DOI
Peer Reviewed
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[Journal Article] Rho-Associated Kinase (ROCK) Activity, Endothelial Function and Cardiovascular Risk Factors2011
Author(s)
Soga J, Noma K, Hata T, Hidaka T, Fujii Y, Idei N, Fujimura N, Mikami S, Maruhashi T, Kihara Y, Chayama K, MD, Kato H, Liao JK, Higashi Y.
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 31
Pages: 2353-2359
DOI
Peer Reviewed
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