Role of thrombospondin and nicotine dependence in vascular damage from smoking

2014 Fiscal Year Final Research Report

• Project/Area Number: 23591056
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Osaka City University
• Principal Investigator: TAKEMOTO Yasuhiko 大阪市立大学, 医学(系)研究科(研究院), 准教授 (20364002)
• Co-Investigator(Kenkyū-buntansha): YOSHIYAMA Minoru 大阪市立大学, 医学(系)研究科(研究院), 教授 (30240956) ; HIROHASHI Kazuhiro 大阪市立大学, 医学(系)研究科(研究院), 教授 (00145799) ; AZUMA Jyunichi 兵庫医療大学, 薬学部, 教授 (30144463) ; FUJIO Yasushi 大阪大学, 薬学研究科(研究院), 教授 (20359839) ; MAEDA Makiko 大阪大学, 薬学研究科(研究院), 講師 (70461168) ; NONEN Shinpei 兵庫医療大学, 薬学部, 講師 (40467527)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 禁煙 / 血管障害 / ニコチン依存度 / トロンボスポンジン / 血管内皮機能

Outline of Final Research Achievements

We evaluated alterations of flow-mediated dilation (FMD) in smokers during smoking cessation with varenicline therapy and found significant increases of FMD. Thrombospondin-1 increases nitric oxide (NO) and suggests the possibility of FMD improvements. However, there were no significant differences of thrombospondin-1 plasma levels between before and after smoking cessation with varenicline therapy. VEGF also increases nitric oxide (NO) and suggests the possibility of FMD improvements. IL-6 induces vascular inflammations and suggests the possibility of FMD deteriorations. However, there were no significant differences of VEGF and IL-6 levels between before and after smoking cessation with varenicline therapy.

Free Research Field

循環器学