2013 Fiscal Year Final Research Report
Pathophysiological effect of circulating monocyte subsets on thrombus formation following by coronary plaque rupture
| Project/Area Number |
23591058
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
IMANISHI Toshio 和歌山県立医科大学, 医学部, 准教授 (00285389)
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| Co-Investigator(Kenkyū-buntansha) |
OZAKI Yuichi 和歌山県立医科大学, 医学部, 学内助教 (00507999)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 血栓 / 単球サブセット / 急性冠症候群 / 冠血管イメージング |
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| Research Abstract |
Although monocytes appear to be actively involved in the onset of acute coronary syndrome (ACS), they are heterogenous in human peripheral blood. We thereofore investigated the relationship between the expression of P-selectin glycoprotein ligand-1 (PSGL-1) on monocyte subsets and thrombus formation using frequency-domain optical coherence tomography (FD-OCT) in patients with ACS. We enrolled patients with acute myocardial infarction (AMI, n=25), unstable angina pectoris (UAP, n=20), or stable angina pectoris (n=35), and control subjects (n=20). The expression of PSGL-1 on circulating peripheral CD14++CD16+ monocytes was significantly elevated in patients with AMI compared with the other 3 groups. The expression levels of PSGL-1 on CD14++CD16+ monocytes were significantly higher in patients with plaque rupture or intracoronary thrombus assessed by FD-OCT. We concluded that up-regulation of PSGL-1 on CD14++CD16+ monocytes may be a crucial role in plaque rupture and thrombus formation.
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[Journal Article] Impact of Glucose Fluctuation and Monocyte Subsets on Coronary Plaque Rupture2014
Author(s)
Teraguchi I, Imanishi T, Ozaki Y, Tanimoto T, Ueyama M, Orii M, Shiono Y, Shimamura K, Yamano T, Ino Y, Yamaguchi T, Hirata K, Kubo T, Sanke T, Akasaka T
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Journal Title
Metabolism & Cardiovascular Diseases
Volume: 24(3)(accepted for publication in Nutrition)
Pages: 309-314
Peer Reviewed
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[Journal Article] Association between P-selectin Glycoprotein and Pathogenesis in Acute Coronary Syndrome Assessed by Optical Coherence Tomography2014
Author(s)
Ozaki Y, Imanishi T, Teraguchi I, Nishiguchi T, Orii M, Shiono Y, Shimamura K, Ishibashi K, Tanimoto T, Yamano T, Ino Y, Yamaguchi T, Kubo T, Akasaka T
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Journal Title
Atherosclerosis
Volume: 233(2)
Pages: 697-703
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[Journal Article] Effect of Direct Renin Inhibitor on Left Ventricular Remodeling in Patients With Primary Acute Myocardial Infarction2014
Author(s)
Ozaki Y, Imanishi T, Tanimoto T, Taraguchi I, Nishiguchi T, Orii M, Shiono Y, Shimamura K, Yamano T, Ino Y, Yamaguchi T, Kubo T, Akasaka T
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Journal Title
Int Heart J.
Volume: 55(1)
Pages: 17-21
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[Journal Article] Effect of the direct renin inhibitor aliskiren on peripheral nlood monocyte subsets and myocardial salvage in patients with primary acute myocardial infarction2012
Author(s)
Ozaki Y, Imanishi T, Kashiwagi M, Tsujioka H, Sougawa H, Orii M, Shiono Y, Shimamura K, Ishibashi K, Komukai K, Ino T, Kitabata H and Akasaka T
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Journal Title
Circ J
Volume: 76(6)
Pages: 1461-1468
Peer Reviewed
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[Journal Article] Differential expression of Toll-like receptor 4 and human monocyte subsets in acute myocardial infarction2012
Author(s)
Kashiwagi M, Imanishi T, Ozaki Y, Satogami K, Masuno T, Wada T, Nakatani Y, Ishibashi K, Komukai K, Tanimoto T, Ino Y, Kitabata H and Akasaka T
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Journal Title
Atherosclerosis
Volume: 221(1)
Pages: 249-253
Peer Reviewed
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[Presentation] 急性期の平均血糖変動幅(MAGE)は急性心筋梗塞(AMI)患者における心筋救済の因子である2013
Author(s)
寺口郁子,今西敏雄,尾﨑雄一,折居誠,塩野泰紹,谷本貴志,山野貴司,山口智由,平田久美子,久保隆史,今西敏雄,久保隆史,赤阪隆史
Organizer
第61回日本心臓病学会学術集会
Place of Presentation
熊本県熊本市
Year and Date
20130900
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[Presentation] 平均血糖変動幅(MAGE)は冠動脈プラーク破裂に影響を与える2013
Author(s)
寺口郁子,今西敏雄,尾﨑雄一,折居誠,塩野泰紹,谷本貴志,山野貴司,山口智由,平田久美子,久保隆史,赤阪隆史
Organizer
第61回日本心臓病学会学術集会
Place of Presentation
熊本県熊本市
Year and Date
20130900
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[Presentation] Impact of glucose fluctuation and monocyte subsets on coronary plaque rupture2013
Author(s)
Teraguchi I, Imanishi T, Ozaki Y, Tanimoto T, Yamano T, Ino Y, Yamaguchi T, Hirata K, Kubo T, Akasaka T
Organizer
European Society Cardiology Congress 2013
Place of Presentation
Amsterdam, Netherlands
Year and Date
20130800
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[Presentation] Circulating CD14+CD16+ Monocyte Subsets as Biomarkers for Severity of Coronary Artery Disease in Patients With Stable Angina Pectoris2012
Author(s)
Ozaki Y, Imanishi T, Aoki H, Orii M, Shiono Y, Shimamura K, Ishibashi K, Tanimoto T, Yamano T, Ino Y, Yamaguchi T, Kubo T and Akasaka T
Organizer
American Heart Association Scientific Sessions 2012
Place of Presentation
Los Angeles, USA
Year and Date
20121100
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