2013 Fiscal Year Final Research Report
Molecular imaging of vascular inflammation in patients with coronary artery disease
| Project/Area Number |
23591072
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIBASHI Masatoshi 久留米大学, 医学部, 教授 (20168256)
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| Co-Investigator(Renkei-kenkyūsha) |
KODAMA Norihiro 久留米大学, 医学部, 助教 (50569382)
UENO Takafumi 久留米大学, 医学部, 教授 (90184952)
MITSUTAKE Yoshiaki 久留米大学, 医学部, 助教 (90511874)
KAIDA Hayato 久留米大学, 医学部, 助教 (40299425)
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| Project Period (FY) |
2011 – 2013
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| Keywords | FDG-PET / 多列化CT / 炎症 / 冠動脈ステント |
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| Research Abstract |
We investigated whether FDG activity in coronary arteries implanted bare-metal stent or drug-eluting stent evaluated by FDG-PET/CT angiography is associated with the post-stenting complications. Intense myocardial FDG uptake hampers to evaluate FDG activity in coronary artery lesions. We could not completely suppress the intense myocardial FDG uptake even with at least 12 hour-fasting and heparin loading prior to PET scan. FDG uptake in the stented coronary artery after stenting was associated with the post-stenting complications such as re-stenosis, endothelial dysfunction, mal-apposition, and stent thrombosis.
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[Journal Article] Effects of pioglitazone on visceral fat metabolic activity in impaired glucose tolerance or type 2 diabetes mellitus2013
Author(s)
Kodama N, Tahara N, Tahara A, Honda A, Nitta Y, Mizoguchi M, Kaida H, Ishibashi M, Abe T, Ikeda H, Narula J, Fukumoto Y, Yamagishi S, Imaizumi T
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Journal Title
J Clin Endocrinol Metab
Volume: 98(11)
Pages: 4438-45
DOI
Peer Reviewed
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[Journal Article] Molecular imaging of human ACE-1 expression in transgenic rats2012
Author(s)
Dilsizian V, Zynda TK, Petrov A, Ohshima S, Tahara N, Haider N, Donohue A, Aras O, Femia FJ, Hillier SM, Joyal JL, Wong ND, Coleman T, Babich JW, Narula J
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Journal Title
JACC Cardiovasc Imaging
Volume: 5(4)
Pages: 409-418
DOI
Peer Reviewed
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[Journal Article] Pioglitazone attenuates atherosclerotic plaque inflammation in patients with impaired glucose tolerance or diabetes a prospective, randomized, comparator-controlled study using serial FDG PET/CT imaging study of carotid artery and ascending aorta2011
Author(s)
Mizoguchi M, Tahara N, Tahara A, Nitta Y, Kodama N, Oba T, Mawatari K, Yasukawa H, Kaida H, Ishibashi M, Hayabuchi N, Harada H, Ikeda H, Yamagishi S, Imaizumi T
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Journal Title
JACC Cardiovasc Imaging
Volume: 4(10)
Pages: 1110-1118
DOI
Peer Reviewed
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[Presentation] Effects of pioglitazone on visceral fat metabolic activity in impaired glucose tolerance or type 2 diabetes mellitus2014
Author(s)
Kodama N,Tahara N, Tahara A, Honda A, Nitta Y, Mizoguchi M, Ishibashi M, Ikeda H, Narula J, Yamagishi S, Imaizumi T
Organizer
第78回日本循環器学会学術集会
Place of Presentation
東京
Year and Date
20140321-23
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[Presentation] 循環器疾患におけるFDG-PET2012
Author(s)
Tahara N, Honda A, Tahara A, Nitta Y, Kodama N, Mizoguchi M, Imaizumi T
Organizer
第76回日本循環器学会学術集会
Place of Presentation
福岡(モーニングレクチャー)
Year and Date
20120316-18
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[Presentation] Serum Levels of Advanced Glycation End Products are Independent Correlates of Vascular Inflammation Evaluated by FDG-PET in Humans2011
Author(s)
Tahara A, Tahara N, Honda A, Kodama N, Nitta Y, Mizoguchi M, Ishibashi M, Matsui T, Yamagishi S, Imaizumi T
Organizer
The American Heart Association, The 84th Scientific Sessions
Place of Presentation
Orland, USA
Year and Date
20111116-20
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