The development of a novel modality treating heart failure patients via the improvement of vascular endothelial function by use of whole body periodic acceleration with a motion platform

2013 Fiscal Year Final Research Report

• Project/Area Number: 23591074
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: The Tazuke Kofukai
• Principal Investigator: MIYAMOTO Shoichi 公益財団法人田附興風会, 医学研究所 第2研究部, 主任研究員 (30435557)
• Co-Investigator(Kenkyū-buntansha): NOHARA Ryuji 公益財団法人田附興風会, 医学研究所第2研究部, 研究主幹 (80180769)
• Co-Investigator(Renkei-kenkyūsha): FUJITA Masatoshi 京都大学, 医学部, 教授 (50190046)
• Project Period (FY): 2011 – 2013
• Keywords: 血管内皮機能

Research Abstract

Objectives: We hypothesized that treatment with whole body periodic acceleration (WBPA) reverses left ventricular (LV) remodeling as a result of increased peripheral vasodilatory reserve in patients with old myocardial infarction (OMI). Methods: Thirteen OMI patients years who received full medication were randomly assigned to undergo 20 sessions of mild WBPA (Control group) or regular WBPA with the motion platform for 4 weeks (WBPA group). Mild WBPA was applied at 2 to 3 Hz and approximately +-0.3 m/sec2 for 45 min and regular WBPA was applied at approximately +-2.2 m/sec2. We repeated the blood sampling and treadmill exercise test. Results: Plasma BNP levels significantly decreased in the regular WBPA group. In the regular WBPA group, the exercise time until dyspnea onset significantly increased, and the double product at 0.1 mV ST depression. Conclusions: Treatment with regular WBPA for OMI patients ameliorates exercise capacity through central and peripheral effects.