2013 Fiscal Year Final Research Report
Epigenetic control of cardiac gene expressions by non-canonical Wnts
| Project/Area Number |
23591083
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MAEDA Toyoki 九州大学, 大学病院, 准教授 (30264112)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | エピジェネテックス / 再生医療 |
|---|
| Research Abstract |
It has been shown that canonical Wnt as well as non-canonical Wnt signal is important to induce cardiac genes. However underlying signal is not well elucidated. We found that non-canonical Wnt5a increase histone lysine methylases and demethylases in endothelial progenitor cells. This increases changed the pattern of methylated histone. These epigenetic changes has been found in hematopoietic stem progenitor cells in human, mouse, and rats, but not on ES cells and MSCs so far.
|
