2013 Fiscal Year Final Research Report
Parity check by gap junctions maintains normal cardiac conduction in sinoatrial node
| Project/Area Number |
23591091
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Tokyo Women's Medical University |
|---|
Principal Investigator |
NISHII Akiko (関 明子) 東京女子医科大学, 医学部, 助教 (80408608)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NISHII Kiyomasa 防衛医科大学校, 医学部, 助教 (20264020)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | ギャップジャンクション / コネキシン45 / 洞結節 / パリティ保証機構 / ノックアウトマウス / 伝導障害 |
|---|
| Research Abstract |
Gap junctions (GJ) are intercellular pathway consisted of protein called connexins (Cx). Cx45 is distributed in whole heart in early embryonic stage and it is restricted in cardiac conduction system in the adult heart. We proposed that parity check by Cx45 is important to maintain normal cardiac conduction. To verify this hypothesis, we built region and time specific Cx45 knockout mice. Both in embryonic and adult heart, Cx45 knockout showed abnormal cardiac conduction. The data are in agreement with the hypothesis.
|
