2013 Fiscal Year Final Research Report
Involvement of cleaved prolactin in peripartum cardiomyopathy
| Project/Area Number |
23591092
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Meiji University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Michiyo 明治大学, 農学部, 講師 (20445860)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMIYA Chizuko 独立行政法人国立循環器病研究センター, 周産期・婦人科部, 医師 (10551301)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 周産期心筋症 / プロラクチン / バソインヒビン |
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| Research Abstract |
It is well known that prolactin (PRL) has modified into several variants. One of these variants, N-terminal PRL which is cleaved by cathepsinD (CathD), is named vasoinhibins (Vi) because of its anti-angiogenic and pro-apototic properties. Vi has been reported the possibility to cause for peripartum cardiomyopathy (PPCM) and pregnancy induced hypertension (PIH) syndrome. In order to clarify these pathogenic mechanisms, we tried to detect Vi value and CathD activity in patient's blood and determine the relationship between these factors and diseases.
Vi content and CathD activity in PPCM and PIH patients are higher than these of control healthy pregnant women. These results seem to suggest that measurement of Vi content and CathD activity is useful for early detection of PPCM and PIH in pregnant women.
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